Effective treatments of prolonged status epilepticus in developing rats

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We determined the efficacy of diazepam (DZP) and pentobarbital (PTB) in controlling prolonged status epilepticus (SE) in developing rats. One-hour-long SE was induced with kainic acid (KA) or lithium pilocarpine (Li-Pilo) in Postnatal Day 9 (P9), 15 (P15) and 21 (P21) rats, which were then treated with varying doses of DZP (20-60 mg/kg) or PTB (20-60 mg/kg). At P9, neither drug stopped SE, and higher doses could not be used because of high mortality. At P15 and P21, DZP and PTB stopped both behavioral and electrographic SE in a dose-dependent fashion, with similar efficacy in the two seizure models. DZP stopped SE significantly faster than PTB. Administration of a low dose of PTB (20 mg/kg) following an initially ineffective treatment with DZP 20 mg/kg stopped SE in all rats. The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.

Original languageEnglish (US)
Pages (from-to)62-69
Number of pages8
JournalEpilepsy and Behavior
Volume13
Issue number1
DOIs
StatePublished - Jul 1 2008

    Fingerprint

Keywords

  • Infant
  • Rodent model
  • Seizure
  • Status epilepticus
  • Treatment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

Cite this