Effective treatments of prolonged status epilepticus in developing rats

Henry Hasson, Mimi Kim, Solomon L. Moshe

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We determined the efficacy of diazepam (DZP) and pentobarbital (PTB) in controlling prolonged status epilepticus (SE) in developing rats. One-hour-long SE was induced with kainic acid (KA) or lithium pilocarpine (Li-Pilo) in Postnatal Day 9 (P9), 15 (P15) and 21 (P21) rats, which were then treated with varying doses of DZP (20-60 mg/kg) or PTB (20-60 mg/kg). At P9, neither drug stopped SE, and higher doses could not be used because of high mortality. At P15 and P21, DZP and PTB stopped both behavioral and electrographic SE in a dose-dependent fashion, with similar efficacy in the two seizure models. DZP stopped SE significantly faster than PTB. Administration of a low dose of PTB (20 mg/kg) following an initially ineffective treatment with DZP 20 mg/kg stopped SE in all rats. The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.

Original languageEnglish (US)
Pages (from-to)62-69
Number of pages8
JournalEpilepsy and Behavior
Volume13
Issue number1
DOIs
StatePublished - Jul 2008

Fingerprint

Status Epilepticus
Pentobarbital
Diazepam
Pilocarpine
Kainic Acid
Lithium
Seizures
Mortality
Pharmaceutical Preparations

Keywords

  • Infant
  • Rodent model
  • Seizure
  • Status epilepticus
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Effective treatments of prolonged status epilepticus in developing rats. / Hasson, Henry; Kim, Mimi; Moshe, Solomon L.

In: Epilepsy and Behavior, Vol. 13, No. 1, 07.2008, p. 62-69.

Research output: Contribution to journalArticle

@article{a97928e4f62045bf963027ca5850fd7d,
title = "Effective treatments of prolonged status epilepticus in developing rats",
abstract = "We determined the efficacy of diazepam (DZP) and pentobarbital (PTB) in controlling prolonged status epilepticus (SE) in developing rats. One-hour-long SE was induced with kainic acid (KA) or lithium pilocarpine (Li-Pilo) in Postnatal Day 9 (P9), 15 (P15) and 21 (P21) rats, which were then treated with varying doses of DZP (20-60 mg/kg) or PTB (20-60 mg/kg). At P9, neither drug stopped SE, and higher doses could not be used because of high mortality. At P15 and P21, DZP and PTB stopped both behavioral and electrographic SE in a dose-dependent fashion, with similar efficacy in the two seizure models. DZP stopped SE significantly faster than PTB. Administration of a low dose of PTB (20 mg/kg) following an initially ineffective treatment with DZP 20 mg/kg stopped SE in all rats. The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.",
keywords = "Infant, Rodent model, Seizure, Status epilepticus, Treatment",
author = "Henry Hasson and Mimi Kim and Moshe, {Solomon L.}",
year = "2008",
month = "7",
doi = "10.1016/j.yebeh.2008.02.008",
language = "English (US)",
volume = "13",
pages = "62--69",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Effective treatments of prolonged status epilepticus in developing rats

AU - Hasson, Henry

AU - Kim, Mimi

AU - Moshe, Solomon L.

PY - 2008/7

Y1 - 2008/7

N2 - We determined the efficacy of diazepam (DZP) and pentobarbital (PTB) in controlling prolonged status epilepticus (SE) in developing rats. One-hour-long SE was induced with kainic acid (KA) or lithium pilocarpine (Li-Pilo) in Postnatal Day 9 (P9), 15 (P15) and 21 (P21) rats, which were then treated with varying doses of DZP (20-60 mg/kg) or PTB (20-60 mg/kg). At P9, neither drug stopped SE, and higher doses could not be used because of high mortality. At P15 and P21, DZP and PTB stopped both behavioral and electrographic SE in a dose-dependent fashion, with similar efficacy in the two seizure models. DZP stopped SE significantly faster than PTB. Administration of a low dose of PTB (20 mg/kg) following an initially ineffective treatment with DZP 20 mg/kg stopped SE in all rats. The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.

AB - We determined the efficacy of diazepam (DZP) and pentobarbital (PTB) in controlling prolonged status epilepticus (SE) in developing rats. One-hour-long SE was induced with kainic acid (KA) or lithium pilocarpine (Li-Pilo) in Postnatal Day 9 (P9), 15 (P15) and 21 (P21) rats, which were then treated with varying doses of DZP (20-60 mg/kg) or PTB (20-60 mg/kg). At P9, neither drug stopped SE, and higher doses could not be used because of high mortality. At P15 and P21, DZP and PTB stopped both behavioral and electrographic SE in a dose-dependent fashion, with similar efficacy in the two seizure models. DZP stopped SE significantly faster than PTB. Administration of a low dose of PTB (20 mg/kg) following an initially ineffective treatment with DZP 20 mg/kg stopped SE in all rats. The data suggest that high doses of DZP and PTB are needed to stop prolonged SE in developing rats, but their effectiveness is age dependent.

KW - Infant

KW - Rodent model

KW - Seizure

KW - Status epilepticus

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=46549085593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46549085593&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2008.02.008

DO - 10.1016/j.yebeh.2008.02.008

M3 - Article

VL - 13

SP - 62

EP - 69

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - 1

ER -