Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 Axis in normalized psoriasis plaques

Leanne M. Johnson-Huang, Mayte Suárez-Farĩas, Mary Sullivan-Whalen, Patricia Gilleaudeau, James G. Krueger, Michelle A. Lowes

Research output: Contribution to journalArticlepeer-review

123 Scopus citations


Narrow-band UVB radiation (NB-UVB) therapy offers a well-established treatment modality for psoriasis. However, despite the common use of this form of treatment, the mechanism of action of NB-UVB is not well understood. We studied a group of 14 patients with moderate-to-severe psoriasis treated with carefully titrated and monitored NB-UVB for 6 weeks. Lesional plaques were classified as normalized (n8) or nonresponsive (n6) based on their histological improvement and normalization. We characterized lesional myeloid dendritic cells (DCs) and T cells and their inflammatory mediators using immunohistochemistry and real-time PCR. NB-UVB suppressed multiple parameters of the IL-23/IL-17 pathway in normalized plaques, but not in nonresponsive plaques. NB-UVB decreased the numbers of CD11c DCs, specifically CD1c CD11c inflammatory DCs, and their products, IL-20, inducible nitric oxide synthase, IL-12/23p40, and IL-23p19. Furthermore, effective NB-UVB suppressed IL-17 and IL-22 mRNAs, which strongly correlated with lesion resolution. Therefore, in addition to its known role in suppressing IFN-γ production, NB-UVB radiation therapy can also target the IL-17 pathway to resolve psoriatic inflammation.

Original languageEnglish (US)
Pages (from-to)2654-2663
Number of pages10
JournalJournal of Investigative Dermatology
Issue number11
StatePublished - Nov 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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