TY - JOUR
T1 - Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 Axis in normalized psoriasis plaques
AU - Johnson-Huang, Leanne M.
AU - Suárez-Farĩas, Mayte
AU - Sullivan-Whalen, Mary
AU - Gilleaudeau, Patricia
AU - Krueger, James G.
AU - Lowes, Michelle A.
PY - 2010/11
Y1 - 2010/11
N2 - Narrow-band UVB radiation (NB-UVB) therapy offers a well-established treatment modality for psoriasis. However, despite the common use of this form of treatment, the mechanism of action of NB-UVB is not well understood. We studied a group of 14 patients with moderate-to-severe psoriasis treated with carefully titrated and monitored NB-UVB for 6 weeks. Lesional plaques were classified as normalized (n8) or nonresponsive (n6) based on their histological improvement and normalization. We characterized lesional myeloid dendritic cells (DCs) and T cells and their inflammatory mediators using immunohistochemistry and real-time PCR. NB-UVB suppressed multiple parameters of the IL-23/IL-17 pathway in normalized plaques, but not in nonresponsive plaques. NB-UVB decreased the numbers of CD11c DCs, specifically CD1c CD11c inflammatory DCs, and their products, IL-20, inducible nitric oxide synthase, IL-12/23p40, and IL-23p19. Furthermore, effective NB-UVB suppressed IL-17 and IL-22 mRNAs, which strongly correlated with lesion resolution. Therefore, in addition to its known role in suppressing IFN-γ production, NB-UVB radiation therapy can also target the IL-17 pathway to resolve psoriatic inflammation.
AB - Narrow-band UVB radiation (NB-UVB) therapy offers a well-established treatment modality for psoriasis. However, despite the common use of this form of treatment, the mechanism of action of NB-UVB is not well understood. We studied a group of 14 patients with moderate-to-severe psoriasis treated with carefully titrated and monitored NB-UVB for 6 weeks. Lesional plaques were classified as normalized (n8) or nonresponsive (n6) based on their histological improvement and normalization. We characterized lesional myeloid dendritic cells (DCs) and T cells and their inflammatory mediators using immunohistochemistry and real-time PCR. NB-UVB suppressed multiple parameters of the IL-23/IL-17 pathway in normalized plaques, but not in nonresponsive plaques. NB-UVB decreased the numbers of CD11c DCs, specifically CD1c CD11c inflammatory DCs, and their products, IL-20, inducible nitric oxide synthase, IL-12/23p40, and IL-23p19. Furthermore, effective NB-UVB suppressed IL-17 and IL-22 mRNAs, which strongly correlated with lesion resolution. Therefore, in addition to its known role in suppressing IFN-γ production, NB-UVB radiation therapy can also target the IL-17 pathway to resolve psoriatic inflammation.
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U2 - 10.1038/jid.2010.166
DO - 10.1038/jid.2010.166
M3 - Article
C2 - 20555351
AN - SCOPUS:77957952423
SN - 0022-202X
VL - 130
SP - 2654
EP - 2663
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 11
ER -