Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 Axis in normalized psoriasis plaques

Leanne M. Johnson-Huang, Mayte Suárez-Farĩas, Mary Sullivan-Whalen, Patricia Gilleaudeau, James G. Krueger, Michelle A. Lowes

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Narrow-band UVB radiation (NB-UVB) therapy offers a well-established treatment modality for psoriasis. However, despite the common use of this form of treatment, the mechanism of action of NB-UVB is not well understood. We studied a group of 14 patients with moderate-to-severe psoriasis treated with carefully titrated and monitored NB-UVB for 6 weeks. Lesional plaques were classified as normalized (n8) or nonresponsive (n6) based on their histological improvement and normalization. We characterized lesional myeloid dendritic cells (DCs) and T cells and their inflammatory mediators using immunohistochemistry and real-time PCR. NB-UVB suppressed multiple parameters of the IL-23/IL-17 pathway in normalized plaques, but not in nonresponsive plaques. NB-UVB decreased the numbers of CD11c DCs, specifically CD1c CD11c inflammatory DCs, and their products, IL-20, inducible nitric oxide synthase, IL-12/23p40, and IL-23p19. Furthermore, effective NB-UVB suppressed IL-17 and IL-22 mRNAs, which strongly correlated with lesion resolution. Therefore, in addition to its known role in suppressing IFN-γ production, NB-UVB radiation therapy can also target the IL-17 pathway to resolve psoriatic inflammation.

Original languageEnglish (US)
Pages (from-to)2654-2663
Number of pages10
JournalJournal of Investigative Dermatology
Volume130
Issue number11
DOIs
StatePublished - Nov 2010
Externally publishedYes

Fingerprint

Interleukin-23
Interleukin-17
Radiotherapy
Psoriasis
Radiation
Dendritic Cells
Interleukin-23 Subunit p19
T-cells
Nitric Oxide Synthase Type II
Myeloid Cells
Interleukin-12
Real-Time Polymerase Chain Reaction
Immunohistochemistry
Inflammation
T-Lymphocytes
Messenger RNA
Therapeutics

ASJC Scopus subject areas

  • Dermatology
  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Johnson-Huang, L. M., Suárez-Farĩas, M., Sullivan-Whalen, M., Gilleaudeau, P., Krueger, J. G., & Lowes, M. A. (2010). Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 Axis in normalized psoriasis plaques. Journal of Investigative Dermatology, 130(11), 2654-2663. https://doi.org/10.1038/jid.2010.166

Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 Axis in normalized psoriasis plaques. / Johnson-Huang, Leanne M.; Suárez-Farĩas, Mayte; Sullivan-Whalen, Mary; Gilleaudeau, Patricia; Krueger, James G.; Lowes, Michelle A.

In: Journal of Investigative Dermatology, Vol. 130, No. 11, 11.2010, p. 2654-2663.

Research output: Contribution to journalArticle

Johnson-Huang, LM, Suárez-Farĩas, M, Sullivan-Whalen, M, Gilleaudeau, P, Krueger, JG & Lowes, MA 2010, 'Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 Axis in normalized psoriasis plaques', Journal of Investigative Dermatology, vol. 130, no. 11, pp. 2654-2663. https://doi.org/10.1038/jid.2010.166
Johnson-Huang LM, Suárez-Farĩas M, Sullivan-Whalen M, Gilleaudeau P, Krueger JG, Lowes MA. Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 Axis in normalized psoriasis plaques. Journal of Investigative Dermatology. 2010 Nov;130(11):2654-2663. https://doi.org/10.1038/jid.2010.166
Johnson-Huang, Leanne M. ; Suárez-Farĩas, Mayte ; Sullivan-Whalen, Mary ; Gilleaudeau, Patricia ; Krueger, James G. ; Lowes, Michelle A. / Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 Axis in normalized psoriasis plaques. In: Journal of Investigative Dermatology. 2010 ; Vol. 130, No. 11. pp. 2654-2663.
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