Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor

Nicholas E. Baker, Gerald M. Rubin

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

THE compound eye of the adult fruitfly, Drosophila melanogaster, comprises about 800 identical ommatidia, or unit eyes, each containing 20 distinct cells. We have used histological and immunocytochemical methods to study the development of the compound eye in Ellipse (Elp) mutants. In Elp/Elp, most ommatidia do not initiate differentiation. We present genetic evidence that Elp alleles are mutations of the Drosophila homologue of the epidermal growth factor (EGF) receptor, and suggest that activity of the EGF receptor may determine the spacing pattern of ommatidia in the eye.

Original languageEnglish (US)
Pages (from-to)150-153
Number of pages4
JournalNature
Volume340
Issue number6229
StatePublished - 1989
Externally publishedYes

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Mutation
Drosophila melanogaster
Epidermal Growth Factor Receptor
Alleles
Drosophila Egfr protein

ASJC Scopus subject areas

  • General

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Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor. / Baker, Nicholas E.; Rubin, Gerald M.

In: Nature, Vol. 340, No. 6229, 1989, p. 150-153.

Research output: Contribution to journalArticle

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