Effect of zafirlukast on cough reflex sensitivity in asthmatics

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In patients with asthma, increased sensitivity of airway sensory nerves may be involved in producing bronchospasm and cough. To evaluate the effect of a leukotriene-modifying agent on cough reflex sensitivity, we measured the cough response to inhaled capsaicin before and after a 14-day course of therapy with zafirlukast, a cysteinyl leukotriene receptor antagonist, in a group of stable asthmatics. The concentration of capsaicin inducing two or more (C2) and five or more (C5) coughs was not altered by zafirlukast, even in those subjects demonstrating a significant change (increment or decrement) in forced expiratory volume in 1 sec (FEV1). These findings support previous evidence that cough and bronchoconstriction are modulated by distinct neural pathways.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalJournal of Asthma
Volume36
Issue number3
StatePublished - 1999

Fingerprint

Cough
Reflex
Capsaicin
Leukotriene Antagonists
Neural Pathways
Bronchial Spasm
Bronchoconstriction
Leukotrienes
Forced Expiratory Volume
Asthma
zafirlukast
Therapeutics

Keywords

  • Asthma
  • Capsaicin
  • Cough
  • Cough-variant asthma
  • Leukotriene receptor antagonists
  • Leukotrienes
  • Zafirlukast

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Effect of zafirlukast on cough reflex sensitivity in asthmatics. / Dicpinigaitis, Peter Vytautas; Dobkin, Jay B.

In: Journal of Asthma, Vol. 36, No. 3, 1999, p. 265-270.

Research output: Contribution to journalArticle

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