Effect of zafirlukast, a leukotriene-receptor antagonist, on cough reflex sensitivity in healthy volunteers: A pilot study

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2 Citations (Scopus)

Abstract

Agents that modify the synthesis or activity of leukotrienes have recently become available for the treatment of asthma. The effect of these agents on cough reflex sensitivity has not previously been investigated. A randomized, double-masked, placebo-controlled, crossover study was conducted in 12 healthy volunteers to evaluate the effect of zafirlukast, a leukotriene-receptor antagonist, on cough reflex sensitivity to inhaled capsaicin. The concentration of capsaicin inducing 2 or more and 5 or more coughs was not altered by a 14-day course of oral zafirlukast. The results of the present study, however, do not exclude a role for leukotriene-modifying agentS in the treatment of pathologic cough.

Original languageEnglish (US)
Pages (from-to)15-19
Number of pages5
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume60
Issue number1
DOIs
StatePublished - 1999

Fingerprint

Leukotriene Antagonists
Cough
Reflex
Healthy Volunteers
Leukotrienes
Capsaicin
Cross-Over Studies
Asthma
Placebos
zafirlukast
Therapeutics

Keywords

  • Capsaicin
  • Cough
  • Leukotriene inhibitors
  • Leukotrienes
  • Zafirlukast

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Agents that modify the synthesis or activity of leukotrienes have recently become available for the treatment of asthma. The effect of these agents on cough reflex sensitivity has not previously been investigated. A randomized, double-masked, placebo-controlled, crossover study was conducted in 12 healthy volunteers to evaluate the effect of zafirlukast, a leukotriene-receptor antagonist, on cough reflex sensitivity to inhaled capsaicin. The concentration of capsaicin inducing 2 or more and 5 or more coughs was not altered by a 14-day course of oral zafirlukast. The results of the present study, however, do not exclude a role for leukotriene-modifying agentS in the treatment of pathologic cough.",
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AB - Agents that modify the synthesis or activity of leukotrienes have recently become available for the treatment of asthma. The effect of these agents on cough reflex sensitivity has not previously been investigated. A randomized, double-masked, placebo-controlled, crossover study was conducted in 12 healthy volunteers to evaluate the effect of zafirlukast, a leukotriene-receptor antagonist, on cough reflex sensitivity to inhaled capsaicin. The concentration of capsaicin inducing 2 or more and 5 or more coughs was not altered by a 14-day course of oral zafirlukast. The results of the present study, however, do not exclude a role for leukotriene-modifying agentS in the treatment of pathologic cough.

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