Effect of transmural vagal stimulation on electrotonic current spread in the rabbit sinoatrial node

J. J. Duivenvoorden, L. N. Bouman, T. Opthof, F. F. Bukauskas, H. J. Jongsma

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: The effect of vagal stimulation on the decay of electrotonic potential caused by intracellular current injection and on input resistance was measured in the sinoatrial node of isolated rabbit right atria. Methods: Studies were performed on New Zealand White rabbits weighing approximately 2-3 kg. Vagal stimulation was achieved by transmural stimulation of intramural nerve fibres in the presence of propranolol. A K+ perfused suction electrode was used to inject hyperpolarising current pulses; input resistance was measured by means of a double barrel microelectrode. Results: Vagal stimulation which caused a 14-20% increase of cycle length diminished electronic potential significantly by a decrease of membrane resistance. The input resistance of the sinoatrial node was not affected. Space constant values calculated by using either a one or a two dimensional model of electrotonic current spread were decreased on average by 13% and 14% respectively. Conclusions: The results from this study show that vagal stimulation which gave rise to a moderate negative chronotropic effect and marked changes in action potential configuration of nodal fibres affects the electrotonic interaction within the sinoatrial node. This may have consequences for the electrical activity and synchronisation of the sinoatrial nodal fibres.

Original languageEnglish (US)
Pages (from-to)678-686
Number of pages9
JournalCardiovascular Research
Volume26
Issue number7
StatePublished - 1992
Externally publishedYes

Fingerprint

Sinoatrial Node
Rabbit
Rabbits
Fibers
Fiber
Vertex of a graph
Microelectrodes
Suction
Weighing
Heart Atria
Nerve Fibers
Propranolol
Action Potentials
Cycle Length
Action Potential
Synchronization
Electrodes
Nerve
Electrode
Membranes

Keywords

  • Electrotonus
  • Input resistance
  • Sinoatrial node
  • Suction electrode
  • Vagal stimulation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology

Cite this

Duivenvoorden, J. J., Bouman, L. N., Opthof, T., Bukauskas, F. F., & Jongsma, H. J. (1992). Effect of transmural vagal stimulation on electrotonic current spread in the rabbit sinoatrial node. Cardiovascular Research, 26(7), 678-686.

Effect of transmural vagal stimulation on electrotonic current spread in the rabbit sinoatrial node. / Duivenvoorden, J. J.; Bouman, L. N.; Opthof, T.; Bukauskas, F. F.; Jongsma, H. J.

In: Cardiovascular Research, Vol. 26, No. 7, 1992, p. 678-686.

Research output: Contribution to journalArticle

Duivenvoorden, JJ, Bouman, LN, Opthof, T, Bukauskas, FF & Jongsma, HJ 1992, 'Effect of transmural vagal stimulation on electrotonic current spread in the rabbit sinoatrial node', Cardiovascular Research, vol. 26, no. 7, pp. 678-686.
Duivenvoorden JJ, Bouman LN, Opthof T, Bukauskas FF, Jongsma HJ. Effect of transmural vagal stimulation on electrotonic current spread in the rabbit sinoatrial node. Cardiovascular Research. 1992;26(7):678-686.
Duivenvoorden, J. J. ; Bouman, L. N. ; Opthof, T. ; Bukauskas, F. F. ; Jongsma, H. J. / Effect of transmural vagal stimulation on electrotonic current spread in the rabbit sinoatrial node. In: Cardiovascular Research. 1992 ; Vol. 26, No. 7. pp. 678-686.
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