Effect of smoking cessation and tobacco type on the risk of cancers of the upper aero-digestive tract in Brazil

Nicolas F. Schlecht, Eduardo L. Franco, Javier Pintos, Luiz P. Kowalski

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Tobacco smoking has long been identified as the most important risk factor for upper aero-digestive tract cancers. To investigate the effect of different tobacco types and the benefit of smoking cessation, we analyzed data from a case-control study of 784 cases of mouth, pharynx, and larynx cancers and 1,578 non-cancer controls in three metropolitan hospital areas in Brazil. Subjects were interviewed as to their smoking and drinking habits, demographics, environmental exposures, occupational history, health characteristics, and diet. Controlling for total tobacco and alcohol consumption, risks for ex-smokers compared with current smokers decreased substantially with time since cessation of the habit. Compared with never smokers, ex-smokers of >20 years had a relative risk (RR) of 1.98 [95% confidence interval (CI) = 1.0-3.8] for all upper aero-digestive tract cancers. RRs for long-term (>20 years) ex-smokers tended to be lower for mouth (RR = 1.61) and pharynx (RR = 1.52) than for larynx (RR = 3.63) cancers. The benefit of quitting was strongest for commercial cigarettes (RR = 1.45, 95% CI = 0.7-3.0) for ex-smokers of >10 years, as compared with smoking of black tobacco (RR = 2.57, 95% CI = 1.4-4.6), cigars (RR = 2.59, 95% CI = 0.6-11.6), and pipe tobacco (RR = 3.40, 95% CI = 1.3-8.8).

Original languageEnglish (US)
Pages (from-to)412-418
Number of pages7
JournalEpidemiology
Volume10
Issue number4
StatePublished - Jul 1999
Externally publishedYes

Fingerprint

Smoking Cessation
Tobacco
Brazil
Gastrointestinal Tract
Neoplasms
Confidence Intervals
Smoking
Pharynx
Tobacco Products
Habits
Laryngeal Neoplasms
Mouth Neoplasms
Urban Hospitals
Environmental Exposure
Tobacco Use
Occupational Health
Larynx
Alcohol Drinking
Drinking
Mouth

Keywords

  • Black tobacco
  • Case-control study
  • Epidemiologic methods
  • Laryngeal neoplasms
  • Oral neoplasms
  • Pharyngeal neoplasms

ASJC Scopus subject areas

  • Epidemiology

Cite this

Schlecht, N. F., Franco, E. L., Pintos, J., & Kowalski, L. P. (1999). Effect of smoking cessation and tobacco type on the risk of cancers of the upper aero-digestive tract in Brazil. Epidemiology, 10(4), 412-418.

Effect of smoking cessation and tobacco type on the risk of cancers of the upper aero-digestive tract in Brazil. / Schlecht, Nicolas F.; Franco, Eduardo L.; Pintos, Javier; Kowalski, Luiz P.

In: Epidemiology, Vol. 10, No. 4, 07.1999, p. 412-418.

Research output: Contribution to journalArticle

Schlecht, NF, Franco, EL, Pintos, J & Kowalski, LP 1999, 'Effect of smoking cessation and tobacco type on the risk of cancers of the upper aero-digestive tract in Brazil', Epidemiology, vol. 10, no. 4, pp. 412-418.
Schlecht, Nicolas F. ; Franco, Eduardo L. ; Pintos, Javier ; Kowalski, Luiz P. / Effect of smoking cessation and tobacco type on the risk of cancers of the upper aero-digestive tract in Brazil. In: Epidemiology. 1999 ; Vol. 10, No. 4. pp. 412-418.
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