Abstract
Aim: To study the effect of silymarin on the levels of tumor markers and MDA (malondialdehyde) - DNA adduct formation during N-nitrosodiethylamine induced hepatocellular carcinoma in male Wistar albino rats. Methods: The levels of AFP, CEA and activities of liver marker enzymes in serum, MDA-DNA immunohistochemistry were done according to standard procedures in the control and experimental groups of rats. Results: Hepatocellular carcinoma was evidenced from significant (p < 0.05) increases of alpha-fetoprotein, carcinoembryonic antigen, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, gamma-glutamyltransferase and 5′-nucleotidase in serum and increased MDA-DNA adducts were also observed in the tissue sections of hepatocellular carcinoma. Silymarin treatment significantly attenuated the alteration of these markers and decreased the levels of MDA-DNA adduct formation. Conclusion: Silymarin could be developed as a promising chemotherapeutic adjuvant for the treatment of liver cancer.
Original language | English (US) |
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Pages (from-to) | 39-44 |
Number of pages | 6 |
Journal | Experimental Oncology |
Volume | 29 |
Issue number | 1 |
State | Published - Mar 2007 |
Externally published | Yes |
Keywords
- AFP
- Flavonoids
- Hepatocellular carcinoma
- MDA-DNA
- N-nitrosodiethylamine
- Silymarin
ASJC Scopus subject areas
- Oncology
- Cancer Research