Abstract
Background: Limited evidence suggests that physical activity may prevent frailty and associated negative outcomes in older adults. Definitive data from large long-term randomized trials are lacking. Objective: To determine whether a long-term, structured, moderate-intensity physical activity program is associated with a lower risk for frailty and whether frailty status alters the effect of physical activity on the reduction in major mobility disability (MMD) risk. Design: Multicenter, single-blind, randomized trial. Setting: 8 centers in the United States. Participants: 1635 community-dwelling adults, aged 70 to 89 years, with functional limitations. Intervention: A structured, moderate-intensity physical activity program incorporating aerobic, resistance, and flexibility activities or a health education program consisting of workshops and stretching exercises. Measurements: Frailty, as defined by the SOF (Study of Osteoporotic Fractures) index, at baseline and 6, 12, and 24 months, and MMD, defined as the inability to walk 400 m, for up to 3.5 years. Results: Over 24 months of follow-up, the risk for frailty (n = 1623) was not statistically significantly different in the physical activity versus the health education group (adjusted prevalence difference, -0.021 [95% CI, -0.049 to 0.007]). Among the 3 criteria of the SOF index, the physical activity intervention was associated with improvement in the inability to rise from a chair (adjusted prevalence difference, -0.050 [CI, -0.081 to -0.020]). Baseline frailty status did not modify the effect of physical activity on reducing incident MMD (P for interaction = 0.91). Limitation: Frailty status was neither an entry criterion nor a randomization stratum. Conclusion: A structured, moderate-intensity physical activity program was not associated with a reduced risk for frailty over 2 years among sedentary, community-dwelling older adults. The beneficial effect of physical activity on the incidence of MMD did not differ between frail and nonfrail participants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 309-316 |
| Number of pages | 8 |
| Journal | Annals of Internal Medicine |
| Volume | 168 |
| Issue number | 5 |
| DOIs | |
| State | Published - Mar 6 2018 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Internal Medicine
Cite this
Effect of physical activity on frailty : Secondary analysis of a randomized controlled trial. / LIFE Study Investigators.
In: Annals of Internal Medicine, Vol. 168, No. 5, 06.03.2018, p. 309-316.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of physical activity on frailty
T2 - Secondary analysis of a randomized controlled trial
AU - LIFE Study Investigators
AU - Trombetti, Andrea
AU - Hars, Mélany
AU - Hsu, Fang Chi
AU - Reid, Kieran F.
AU - Church, Timothy S.
AU - Gill, Thomas M.
AU - King, Abby C.
AU - Liu, Christine K.
AU - Manini, Todd M.
AU - McDermott, Mary M.
AU - Newman, Anne B.
AU - Rejeski, W. Jack
AU - Guralnik, Jack M.
AU - Pahor, Marco
AU - Fielding, Roger A.
AU - Leeuwenburgh, Christiaan
AU - Caudle, Connie
AU - Crump, Lauren
AU - Holmes, Latonia
AU - Lee, Jocelyn
AU - Lu, Ching Ju
AU - Miller, Michael E.
AU - Espeland, Mark A.
AU - Ambrosius, Walter T.
AU - Applegate, William
AU - Beavers, Daniel P.
AU - Byington, Robert P.
AU - Cook, Delilah
AU - Furberg, Curt D.
AU - Harvin, Lea N.
AU - Henkin, Leora
AU - Hepler, John
AU - Lovato, Laura
AU - Roberson, Wesley
AU - Rushing, Julia
AU - Rushing, Scott
AU - Stowe, Cynthia L.
AU - Walkup, Michael P.
AU - Hire, Don
AU - Katula, Jeffrey A.
AU - Brubaker, Peter H.
AU - Mihalko, Shannon L.
AU - Jennings, Janine M.
AU - Hadley, Evan C.
AU - Romashkan, Sergei
AU - Patel, Kushang V.
AU - Bonds, Denise
AU - Spring, Bonnie
AU - Hauser, Joshua
AU - Verghese, Joe
PY - 2018/3/6
Y1 - 2018/3/6
N2 - Background: Limited evidence suggests that physical activity may prevent frailty and associated negative outcomes in older adults. Definitive data from large long-term randomized trials are lacking. Objective: To determine whether a long-term, structured, moderate-intensity physical activity program is associated with a lower risk for frailty and whether frailty status alters the effect of physical activity on the reduction in major mobility disability (MMD) risk. Design: Multicenter, single-blind, randomized trial. Setting: 8 centers in the United States. Participants: 1635 community-dwelling adults, aged 70 to 89 years, with functional limitations. Intervention: A structured, moderate-intensity physical activity program incorporating aerobic, resistance, and flexibility activities or a health education program consisting of workshops and stretching exercises. Measurements: Frailty, as defined by the SOF (Study of Osteoporotic Fractures) index, at baseline and 6, 12, and 24 months, and MMD, defined as the inability to walk 400 m, for up to 3.5 years. Results: Over 24 months of follow-up, the risk for frailty (n = 1623) was not statistically significantly different in the physical activity versus the health education group (adjusted prevalence difference, -0.021 [95% CI, -0.049 to 0.007]). Among the 3 criteria of the SOF index, the physical activity intervention was associated with improvement in the inability to rise from a chair (adjusted prevalence difference, -0.050 [CI, -0.081 to -0.020]). Baseline frailty status did not modify the effect of physical activity on reducing incident MMD (P for interaction = 0.91). Limitation: Frailty status was neither an entry criterion nor a randomization stratum. Conclusion: A structured, moderate-intensity physical activity program was not associated with a reduced risk for frailty over 2 years among sedentary, community-dwelling older adults. The beneficial effect of physical activity on the incidence of MMD did not differ between frail and nonfrail participants.
AB - Background: Limited evidence suggests that physical activity may prevent frailty and associated negative outcomes in older adults. Definitive data from large long-term randomized trials are lacking. Objective: To determine whether a long-term, structured, moderate-intensity physical activity program is associated with a lower risk for frailty and whether frailty status alters the effect of physical activity on the reduction in major mobility disability (MMD) risk. Design: Multicenter, single-blind, randomized trial. Setting: 8 centers in the United States. Participants: 1635 community-dwelling adults, aged 70 to 89 years, with functional limitations. Intervention: A structured, moderate-intensity physical activity program incorporating aerobic, resistance, and flexibility activities or a health education program consisting of workshops and stretching exercises. Measurements: Frailty, as defined by the SOF (Study of Osteoporotic Fractures) index, at baseline and 6, 12, and 24 months, and MMD, defined as the inability to walk 400 m, for up to 3.5 years. Results: Over 24 months of follow-up, the risk for frailty (n = 1623) was not statistically significantly different in the physical activity versus the health education group (adjusted prevalence difference, -0.021 [95% CI, -0.049 to 0.007]). Among the 3 criteria of the SOF index, the physical activity intervention was associated with improvement in the inability to rise from a chair (adjusted prevalence difference, -0.050 [CI, -0.081 to -0.020]). Baseline frailty status did not modify the effect of physical activity on reducing incident MMD (P for interaction = 0.91). Limitation: Frailty status was neither an entry criterion nor a randomization stratum. Conclusion: A structured, moderate-intensity physical activity program was not associated with a reduced risk for frailty over 2 years among sedentary, community-dwelling older adults. The beneficial effect of physical activity on the incidence of MMD did not differ between frail and nonfrail participants.
UR - http://www.scopus.com/inward/record.url?scp=85042929582&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042929582&partnerID=8YFLogxK
U2 - 10.7326/M16-2011
DO - 10.7326/M16-2011
M3 - Article
C2 - 29310138
AN - SCOPUS:85042929582
VL - 168
SP - 309
EP - 316
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
SN - 0003-4819
IS - 5
ER -