Effect of peritoneal and gastric irrigation with ozonated saline on arterial and venous blood gas values

Jason Fish, Jeff Healy, Rob Gensure, Ella Choe, John Ferrara

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Ozone, a proven in vitro antiseptic agent, has been shown in vivo to reduce infectious morbidity when used as a lavage solution in rodent fecal peritonitis. As concern that absorption of hydroxyl radical byproducts of ozone breakdown might be deleterious to blood buffering capacity, the effects of a 5 minute intragastric or peritoneal lavage with ozonated saline on rodent arterial and venous blood gas values were determined. Compared to values obtained following lavage with oxygenated saline or normal saline, ozonated saline irrigation produced no appreciable alterations in arterial or venous pH, pO2, and pCO2 over a 1 hour observation period. Short-term ozonated saline peritoneal lavage does not appreciably effect rodent blood buffering capacity.

Original languageEnglish (US)
Pages (from-to)1867-1872
Number of pages6
JournalLife Sciences
Volume53
Issue number25
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Gastric Lavage
Peritoneal Lavage
Irrigation
Rodentia
Blood
Gases
Ozone
Therapeutic Irrigation
Local Anti-Infective Agents
Peritonitis
Hydroxyl Radical
Byproducts
Observation
Morbidity

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of peritoneal and gastric irrigation with ozonated saline on arterial and venous blood gas values. / Fish, Jason; Healy, Jeff; Gensure, Rob; Choe, Ella; Ferrara, John.

In: Life Sciences, Vol. 53, No. 25, 1993, p. 1867-1872.

Research output: Contribution to journalArticle

Fish, Jason ; Healy, Jeff ; Gensure, Rob ; Choe, Ella ; Ferrara, John. / Effect of peritoneal and gastric irrigation with ozonated saline on arterial and venous blood gas values. In: Life Sciences. 1993 ; Vol. 53, No. 25. pp. 1867-1872.
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