Abstract
Female Tg rasH2 (CB6F1/Jic-TgrasH2@Tac) mice were administered water once daily, water twice daily with 8 or 12 hours between doses, 1% sodium dodecyl sulfate in water (1% SDS) once daily, or 1% SDS twice daily with 12 hours between doses by oral gavage at volumes of 10 ml/kg/day for 28 or 29 consecutive days. A control group of mice received no treatment and no sham manipulation. There were no significant differences in body weight or food consumption between treated groups and untreated control mice. Mean weights of spleens, livers, and thymuses were lower than control values in most groups of mice subjected to gavage. Focal or multifocal loss of thymic cortical architecture was observed in 13 of 50 mice distributed among all groups (including naïve controls), however only in one instance was this finding suggestive of a precursor to neoplasia. This study demonstrated that Tg rasH2 mice can tolerate once or twice daily gavage dosing with water or vehicle containing 1% SDS. Loss of thymic cortical architecture was a common incidental finding in female Tg rasH2 mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 413-417 |
| Number of pages | 5 |
| Journal | Toxicologic Pathology |
| Volume | 32 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 2004 |
| Externally published | Yes |
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Keywords
- Carcinogenicity
- Gavage
- Mouse
- Sodium dodecyl sulfate
- Tg rasH2
- Thymus
- Transgenic
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Toxicology
- Health, Toxicology and Mutagenesis
Cite this
Effect of oral gavage dosing regimens in female Tg rasH2 transgenic mice. / Morton, Daniel; Sellers, Rani S.; Furst, Sylvia M.; Hawley, Kristen D.; May, Jeffrey R.
In: Toxicologic Pathology, Vol. 32, No. 4, 07.2004, p. 413-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of oral gavage dosing regimens in female Tg rasH2 transgenic mice
AU - Morton, Daniel
AU - Sellers, Rani S.
AU - Furst, Sylvia M.
AU - Hawley, Kristen D.
AU - May, Jeffrey R.
PY - 2004/7
Y1 - 2004/7
N2 - Female Tg rasH2 (CB6F1/Jic-TgrasH2@Tac) mice were administered water once daily, water twice daily with 8 or 12 hours between doses, 1% sodium dodecyl sulfate in water (1% SDS) once daily, or 1% SDS twice daily with 12 hours between doses by oral gavage at volumes of 10 ml/kg/day for 28 or 29 consecutive days. A control group of mice received no treatment and no sham manipulation. There were no significant differences in body weight or food consumption between treated groups and untreated control mice. Mean weights of spleens, livers, and thymuses were lower than control values in most groups of mice subjected to gavage. Focal or multifocal loss of thymic cortical architecture was observed in 13 of 50 mice distributed among all groups (including naïve controls), however only in one instance was this finding suggestive of a precursor to neoplasia. This study demonstrated that Tg rasH2 mice can tolerate once or twice daily gavage dosing with water or vehicle containing 1% SDS. Loss of thymic cortical architecture was a common incidental finding in female Tg rasH2 mice.
AB - Female Tg rasH2 (CB6F1/Jic-TgrasH2@Tac) mice were administered water once daily, water twice daily with 8 or 12 hours between doses, 1% sodium dodecyl sulfate in water (1% SDS) once daily, or 1% SDS twice daily with 12 hours between doses by oral gavage at volumes of 10 ml/kg/day for 28 or 29 consecutive days. A control group of mice received no treatment and no sham manipulation. There were no significant differences in body weight or food consumption between treated groups and untreated control mice. Mean weights of spleens, livers, and thymuses were lower than control values in most groups of mice subjected to gavage. Focal or multifocal loss of thymic cortical architecture was observed in 13 of 50 mice distributed among all groups (including naïve controls), however only in one instance was this finding suggestive of a precursor to neoplasia. This study demonstrated that Tg rasH2 mice can tolerate once or twice daily gavage dosing with water or vehicle containing 1% SDS. Loss of thymic cortical architecture was a common incidental finding in female Tg rasH2 mice.
KW - Carcinogenicity
KW - Gavage
KW - Mouse
KW - Sodium dodecyl sulfate
KW - Tg rasH2
KW - Thymus
KW - Transgenic
UR - http://www.scopus.com/inward/record.url?scp=3442885191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3442885191&partnerID=8YFLogxK
U2 - 10.1080/01926230490457567
DO - 10.1080/01926230490457567
M3 - Article
C2 - 15204964
AN - SCOPUS:3442885191
VL - 32
SP - 413
EP - 417
JO - Toxicologic Pathology
JF - Toxicologic Pathology
SN - 0192-6233
IS - 4
ER -