Effect of object transport on grasp coordination in multiple system atrophy

Lisa M. Muratori, Geraldine Dapul, Matthew N. Bartels, Andrew M. Gordon

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We examined the effects of the parkinsonian variant of multiple-system atrophy (MSA-P) on grasp and forward transport and release of an object. Twelve patients with MSA-P and 10 age-matched control subjects performed the task with each of three object weights (200, 400, 800 gm). Subjects moved at a self-selected pace using a precision grip. The grip (normal) and load (tangential) forces and the object position were recorded. Results indicate subjects with MSA-P have temporal and force coordination deficits. Temporal delays were seen in all subjects with MSA-P, leading to prolonged overall movement times compared to control subjects. These delays occurred throughout the task, with significantly longer transport phases and delays releasing the object. Despite demonstrating an appropriate anticipatory scaling of forces, with increasing grip and load forces for heavier weights, force coordination was compromised in subjects with MSA-P. These subjects generated significant negative load forces prior to transporting the object. In addition, during the transport phase, subjects with MSA-P generated highly variable grip forces. Overall, the results indicate that subjects with MSA-P demonstrate bradykinesia and difficulty coordinating components of an object transport task.

Original languageEnglish (US)
Pages (from-to)555-563
Number of pages9
JournalMovement Disorders
Volume21
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Multiple System Atrophy
Hand Strength
Weights and Measures
Hypokinesia

Keywords

  • Bradykinesia
  • Hand
  • Manual transport
  • Multiple-system atrophy
  • Parkinson's disease
  • Precision grip

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effect of object transport on grasp coordination in multiple system atrophy. / Muratori, Lisa M.; Dapul, Geraldine; Bartels, Matthew N.; Gordon, Andrew M.

In: Movement Disorders, Vol. 21, No. 4, 04.2006, p. 555-563.

Research output: Contribution to journalArticle

Muratori, Lisa M. ; Dapul, Geraldine ; Bartels, Matthew N. ; Gordon, Andrew M. / Effect of object transport on grasp coordination in multiple system atrophy. In: Movement Disorders. 2006 ; Vol. 21, No. 4. pp. 555-563.
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