TY - JOUR
T1 - Effect of neurotrophic factors on the inner ear
T2 - Clinical implications
AU - Kopke, Richard
AU - Staecker, Hinrich
AU - Lefebvre, Philippe
AU - Malgrange, Bridgitte
AU - Moonen, Gustave
AU - Ruben, Robert J.
AU - Van De Water, Thomas R.
N1 - Funding Information:
ACKNOWLEDGEMENTS This work was supported by NIDCD grant DC00008 to TRV, National Fund for Scientific Research of Belgium to PPL and GM.
PY - 1996
Y1 - 1996
N2 - Loss of auditory neurons is commonly associated with sensorineural deafness, and may result from either direct neuronal injury or be a consequence of sensory hair cell loss (i.e. loss of a source of trophic factors). Developmental studies and in vitro studies of adult auditory neurons have begun to identify growth factors important for the development, maintenance, and rescue/repair of auditory neurons. Specific neurotrophic factors have been shown to enhance the auditory neurons' ability to withstand traumatic loss of target tissue connections and toxic injury. Promising initial in vivo studies confirm that specific neurotrophins are able to support neuronal survival and promote neuronal repair in an intact animal following injury to the cochlea. Further study into unique methods and routes of growth factor delivery will provide insights into the possibility of neurotrophic growth factors to act as drugs for the treatment of injured or stressed auditory neurons.
AB - Loss of auditory neurons is commonly associated with sensorineural deafness, and may result from either direct neuronal injury or be a consequence of sensory hair cell loss (i.e. loss of a source of trophic factors). Developmental studies and in vitro studies of adult auditory neurons have begun to identify growth factors important for the development, maintenance, and rescue/repair of auditory neurons. Specific neurotrophic factors have been shown to enhance the auditory neurons' ability to withstand traumatic loss of target tissue connections and toxic injury. Promising initial in vivo studies confirm that specific neurotrophins are able to support neuronal survival and promote neuronal repair in an intact animal following injury to the cochlea. Further study into unique methods and routes of growth factor delivery will provide insights into the possibility of neurotrophic growth factors to act as drugs for the treatment of injured or stressed auditory neurons.
KW - Auditory neurons
KW - Brain derived neurotrophic factor (BDNF)
KW - Neuritogenesis
KW - Neuronal survival
KW - Neurotrophin-3 (NT-3)
KW - Sensorineural deafness
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U2 - 10.3109/00016489609137834
DO - 10.3109/00016489609137834
M3 - Article
C2 - 8725525
AN - SCOPUS:0029869398
SN - 0001-6489
VL - 116
SP - 248
EP - 252
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
IS - 2
ER -