Effect of natalizumab on oxidative damage biomarkers in relapsing-remitting multiple sclerosis

Inmaculada Tasset, Carmen Bahamonde, Eduardo Agüera, Cristina Conde, Antonio H. Cruz, Aleyda Pérez-Herrera, Félix Gascón, Ana I. Giraldo, María C. Ruiz, Rafael Lillo, Fernando Sánchez-López, Isaac Túnez

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: Natalizumab is a monoclonal antibody used to treat multiple sclerosis. This study sought to determine whether the protective action of natalizumab involved a reduction in oxidative damage. Methods: Twenty-two multiple sclerosis patients fulfilling the revised McDonald criteria were assigned to treatment with 300 mg natalizumab intravenously once monthly (infusion every 4 weeks) in accordance with Spanish guidelines. Carbonylated proteins, 8-hydroxy-2'-deoxyguanosine, total glutathione, reduced glutathione, superoxide dismutase, glutathione peroxidase, and myeloperoxidase levels were measured at baseline and after 14 months' treatment, and the antioxidant gap was calculated. Results: Natalizumab prompted a drop in oxidative-damage biomarker levels, together with a reduction both in myeloperoxidase levels and in the myeloperoxidase/neutrophil granulocyte ratio. Interestingly, natalizumab induced nuclear translocation of Nrf2 and a fall in serum vascular cell adhesion molecule-1 levels. Conclusion: These findings suggest that natalizumab has a beneficial effect on oxidative damage found in MS patients.

Original languageEnglish (US)
Pages (from-to)624-631
Number of pages8
JournalPharmacological Reports
Volume65
Issue number3
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Adhesion molecules
  • Multiple sclerosis
  • Natalizumab
  • Nrf2
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology

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    Tasset, I., Bahamonde, C., Agüera, E., Conde, C., Cruz, A. H., Pérez-Herrera, A., Gascón, F., Giraldo, A. I., Ruiz, M. C., Lillo, R., Sánchez-López, F., & Túnez, I. (2013). Effect of natalizumab on oxidative damage biomarkers in relapsing-remitting multiple sclerosis. Pharmacological Reports, 65(3), 624-631. https://doi.org/10.1016/S1734-1140(13)71039-9