Effect of milrinone on steady-state digoxin levels in congestive heart failure

Kevin J. Ferrick; Aileen M. Ferrick; Steven A. Fein; Joseph T. Doyle

doi:10.1016/0002-9149(89)90812-6

Effect of milrinone on steady-state digoxin levels in congestive heart failure

Kevin J. Ferrick, Aileen M. Ferrick, Steven A. Fein, Joseph T. Doyle

Research output: Contribution to journal › Article › peer-review

Abstract

A variety of cardioactive agents have been shown to affect the pharmacokinetics of digoxin and thereby alter serum digoxin levels. Since the first reports describing the digoxin-quinidine interaction,^1,2 numerous agents have been shown to increase serum digoxin levels.^3-6 Milrinone is a nonglycoside, noncatecholamine inotropic agent currently undergoing investigation for the treatment of congestive heart failure. Because many patients receive digoxin for the treatment of heart failure, we attempted to determine retrospectively if milrinone significantly affects steady-state digoxin levels in a heart failure population.

Original language	English (US)
Pages (from-to)	1057
Number of pages	1
Journal	The American Journal of Cardiology
Volume	64
Issue number	16
DOIs	https://doi.org/10.1016/0002-9149(89)90812-6
State	Published - Nov 1 1989
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0002-9149(89)90812-6

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title = "Effect of milrinone on steady-state digoxin levels in congestive heart failure",

abstract = "A variety of cardioactive agents have been shown to affect the pharmacokinetics of digoxin and thereby alter serum digoxin levels. Since the first reports describing the digoxin-quinidine interaction,1,2 numerous agents have been shown to increase serum digoxin levels.3-6 Milrinone is a nonglycoside, noncatecholamine inotropic agent currently undergoing investigation for the treatment of congestive heart failure. Because many patients receive digoxin for the treatment of heart failure, we attempted to determine retrospectively if milrinone significantly affects steady-state digoxin levels in a heart failure population.",

author = "Ferrick, {Kevin J.} and Ferrick, {Aileen M.} and Fein, {Steven A.} and Doyle, {Joseph T.}",

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AU - Ferrick, Kevin J.

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AU - Fein, Steven A.

AU - Doyle, Joseph T.

PY - 1989/11/1

Y1 - 1989/11/1

N2 - A variety of cardioactive agents have been shown to affect the pharmacokinetics of digoxin and thereby alter serum digoxin levels. Since the first reports describing the digoxin-quinidine interaction,1,2 numerous agents have been shown to increase serum digoxin levels.3-6 Milrinone is a nonglycoside, noncatecholamine inotropic agent currently undergoing investigation for the treatment of congestive heart failure. Because many patients receive digoxin for the treatment of heart failure, we attempted to determine retrospectively if milrinone significantly affects steady-state digoxin levels in a heart failure population.

AB - A variety of cardioactive agents have been shown to affect the pharmacokinetics of digoxin and thereby alter serum digoxin levels. Since the first reports describing the digoxin-quinidine interaction,1,2 numerous agents have been shown to increase serum digoxin levels.3-6 Milrinone is a nonglycoside, noncatecholamine inotropic agent currently undergoing investigation for the treatment of congestive heart failure. Because many patients receive digoxin for the treatment of heart failure, we attempted to determine retrospectively if milrinone significantly affects steady-state digoxin levels in a heart failure population.

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JO - The American Journal of Cardiology

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Effect of milrinone on steady-state digoxin levels in congestive heart failure

Abstract

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