A variety of cardioactive agents have been shown to affect the pharmacokinetics of digoxin and thereby alter serum digoxin levels. Since the first reports describing the digoxin-quinidine interaction,1,2 numerous agents have been shown to increase serum digoxin levels.3-6 Milrinone is a nonglycoside, noncatecholamine inotropic agent currently undergoing investigation for the treatment of congestive heart failure. Because many patients receive digoxin for the treatment of heart failure, we attempted to determine retrospectively if milrinone significantly affects steady-state digoxin levels in a heart failure population.
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine