Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice

A. Cruz, Inmaculada Tasset, L. M. Ramírez, A. Arjona, J. Segura, I. Túnez, P. Montilla, J. Muntané, Francisco J. Padillo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions. Material and methods: we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 μg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue. Results: obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium. Conclusions: melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.

Original languageEnglish (US)
Pages (from-to)460-463
Number of pages4
JournalRevista Espanola de Enfermedades Digestivas
Volume101
Issue number7
StatePublished - Jul 2009
Externally publishedYes

Fingerprint

Obstructive Jaundice
Melatonin
Cholestasis
Oxidative Stress
Antioxidants
Malondialdehyde
Glutathione
Enzymes
Bile Ducts
Catalase
Superoxide Dismutase
Ligation
Myocardium
Research

Keywords

  • Antioxidants
  • Cardiac dysfunction
  • Cholestasis
  • Melatonin
  • Oxidative stress

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cruz, A., Tasset, I., Ramírez, L. M., Arjona, A., Segura, J., Túnez, I., ... Padillo, F. J. (2009). Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice. Revista Espanola de Enfermedades Digestivas, 101(7), 460-463.

Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice. / Cruz, A.; Tasset, Inmaculada; Ramírez, L. M.; Arjona, A.; Segura, J.; Túnez, I.; Montilla, P.; Muntané, J.; Padillo, Francisco J.

In: Revista Espanola de Enfermedades Digestivas, Vol. 101, No. 7, 07.2009, p. 460-463.

Research output: Contribution to journalArticle

Cruz, A, Tasset, I, Ramírez, LM, Arjona, A, Segura, J, Túnez, I, Montilla, P, Muntané, J & Padillo, FJ 2009, 'Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice', Revista Espanola de Enfermedades Digestivas, vol. 101, no. 7, pp. 460-463.
Cruz, A. ; Tasset, Inmaculada ; Ramírez, L. M. ; Arjona, A. ; Segura, J. ; Túnez, I. ; Montilla, P. ; Muntané, J. ; Padillo, Francisco J. / Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice. In: Revista Espanola de Enfermedades Digestivas. 2009 ; Vol. 101, No. 7. pp. 460-463.
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AU - Segura, J.

AU - Túnez, I.

AU - Montilla, P.

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AB - Objective: melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions. Material and methods: we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 μg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue. Results: obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium. Conclusions: melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.

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