Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice

A. Cruz; I. Tasset; L. M. Ramírez; A. Arjona; J. Segura; I. Túnez; P. Montilla; J. Muntané; Francisco J. Padillo

doi:10.4321/S1130-01082009000700002

Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice

A. Cruz, I. Tasset, L. M. Ramírez, A. Arjona, J. Segura, I. Túnez, P. Montilla, J. Muntané, Francisco J. Padillo

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective: melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions. Material and methods: we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 μg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue. Results: obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium. Conclusions: melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.

Original language	English (US)
Pages (from-to)	460-463
Number of pages	4
Journal	Revista Espanola de Enfermedades Digestivas
Volume	101
Issue number	7
DOIs	https://doi.org/10.4321/S1130-01082009000700002
State	Published - Jul 2009
Externally published	Yes

Keywords

Antioxidants
Cardiac dysfunction
Cholestasis
Melatonin
Oxidative stress

ASJC Scopus subject areas

Gastroenterology

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10.4321/S1130-01082009000700002

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title = "Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice",

abstract = "Objective: melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions. Material and methods: we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 μg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue. Results: obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium. Conclusions: melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.",

keywords = "Antioxidants, Cardiac dysfunction, Cholestasis, Melatonin, Oxidative stress",

author = "A. Cruz and I. Tasset and Ram{\'i}rez, {L. M.} and A. Arjona and J. Segura and I. T{\'u}nez and P. Montilla and J. Muntan{\'e} and Padillo, {Francisco J.}",

year = "2009",

month = jul,

doi = "10.4321/S1130-01082009000700002",

language = "English (US)",

volume = "101",

pages = "460--463",

journal = "Revista Espanola de Enfermedades Digestivas",

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T1 - Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice

AU - Cruz, A.

AU - Tasset, I.

AU - Ramírez, L. M.

AU - Arjona, A.

AU - Segura, J.

AU - Túnez, I.

AU - Montilla, P.

AU - Muntané, J.

AU - Padillo, Francisco J.

PY - 2009/7

Y1 - 2009/7

N2 - Objective: melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions. Material and methods: we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 μg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue. Results: obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium. Conclusions: melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.

AB - Objective: melatonin has been demonstrated to have active antioxidant properties in different tissues during experimental cholestasis. The aim of this research was to study myocardial oxidative stress on obstructive jaundice, and to analyze the effect of melatonin on myocardial oxidative lesions. Material and methods: we achieved cholestasis by ligature and sectioning of the main bile duct. Melatonin was administered intraperitoneally (500 μg/kg/day). We measured malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxydase (GPx) antioxidant enzyme levels in the heart tissue. Results: obstructive cholestasis increased MDA and decreased GSH as well as all antioxidant enzymes. Melatonin administration significantly decreased MDA values, and increased GSH and antioxidant enzymes on the icteric animal myocardium. Conclusions: melatonin treatment prevents oxidative stress in the cardiac tissue as induced by experimental cholestasis.

KW - Antioxidants

KW - Cardiac dysfunction

KW - Cholestasis

KW - Melatonin

KW - Oxidative stress

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Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice

Abstract

Keywords

ASJC Scopus subject areas

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