Effect of maternal CD4+ cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection

G. Lambert, D. M. Thea, V. Pliner, R. W. Steketee, E. J. Abrams, P. Matheson, P. A. Thomas, B. Greenberg, T. M. Brown, M. Bamjl, M. L. Kalish, S. Beatrice, M. A. Chiasson, E. Debernardo, K. McVeigh, R. O'Donnell, W. Oleszko, A. Punsalang, T. Alford, A. BelmoreA. Betre, M. Capelli, N. Carrasquillo, R. Courtland, N. Cruz, J. Floyd, V. Foye-Sousou, C. Gonzales, L. Jackson, D. J. Jessop, D. Lopez, L. Macias, D. Ng, J. Weedon, S. Young, Z. R. Zhang, M. Allen, W. Borkowsky, W. Hoover, K. Krasinski, H. Pollack, S. Champion, C. Freedland, M. Heagarty, P. Prince, M. Suarez, J. Chow, A. Kaul, S. Nachman, K. Shah, S. Ahmed, E. Agostin, R. Henriquez, E. Sacharzky, S. Losub, R. Brotman, S. Blanch, J. Brutus, C. Day, D. Hutson, W. Rhinehart, R. Simon, V. Turkell, K. T. Grimm, M. Crane, P. Campbell, S. Davila, J. Dobrosyzcki, D. Grant, I. Hand, A. Harris, M. Nieves, L. Solomon, A. Steiner, A. Wiznia, G. Brooks, M. Nicholson, Marguerite M. Mayers, M. Naccarato, Ellie Schoenbaum, M. Sivappalasingham, J. R. George, B. Kilbourne, C. Y. Ou, J. Rapier, J. Petent, N. Schable, N. Shaffer, L. Smith

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Among a cohort of 152 infants perinatally infected with human immunodeficiency virus type 1, and their mothers we correlated infant outcome with maternal CD4+ lymphocyte count and the presence of maternal acquired immunodeficiency syndrome near delivery. In a subset of 50 mother-infant pairs, we also correlated infant outcome with maternal quantitative viral burden as measured by the nucleic acid sequence based amplification system. We found that low maternal CD4+ cell count and high viral burden were associated with decreased time to category C disease or death in infants infected with human immunodeficiency virus type 1. In a multivariate analysis, high maternal viral load and maternal acquired immunodeficiency syndrome were independently associated with shorter time to category c disease or death in infants with human immunodeficiency virus type 1 infection. High viral load in pregnant women, independent of the presence of advanced maternal disease, appears to increase the risk of rapidly progressive disease in their infected offspring.

Original languageEnglish (US)
Pages (from-to)890-897
Number of pages8
JournalJournal of Pediatrics
Volume130
Issue number6
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Virus Diseases
CD4 Lymphocyte Count
Viral Load
Disease Progression
HIV-1
Acquired Immunodeficiency Syndrome
Mothers
Self-Sustained Sequence Replication
Pregnant Women
Multivariate Analysis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Effect of maternal CD4+ cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection. / Lambert, G.; Thea, D. M.; Pliner, V.; Steketee, R. W.; Abrams, E. J.; Matheson, P.; Thomas, P. A.; Greenberg, B.; Brown, T. M.; Bamjl, M.; Kalish, M. L.; Beatrice, S.; Chiasson, M. A.; Debernardo, E.; McVeigh, K.; O'Donnell, R.; Oleszko, W.; Punsalang, A.; Alford, T.; Belmore, A.; Betre, A.; Capelli, M.; Carrasquillo, N.; Courtland, R.; Cruz, N.; Floyd, J.; Foye-Sousou, V.; Gonzales, C.; Jackson, L.; Jessop, D. J.; Lopez, D.; Macias, L.; Ng, D.; Weedon, J.; Young, S.; Zhang, Z. R.; Allen, M.; Borkowsky, W.; Hoover, W.; Krasinski, K.; Pollack, H.; Champion, S.; Freedland, C.; Heagarty, M.; Prince, P.; Suarez, M.; Chow, J.; Kaul, A.; Nachman, S.; Shah, K.; Ahmed, S.; Agostin, E.; Henriquez, R.; Sacharzky, E.; Losub, S.; Brotman, R.; Blanch, S.; Brutus, J.; Day, C.; Hutson, D.; Rhinehart, W.; Simon, R.; Turkell, V.; Grimm, K. T.; Crane, M.; Campbell, P.; Davila, S.; Dobrosyzcki, J.; Grant, D.; Hand, I.; Harris, A.; Nieves, M.; Solomon, L.; Steiner, A.; Wiznia, A.; Brooks, G.; Nicholson, M.; Mayers, Marguerite M.; Naccarato, M.; Schoenbaum, Ellie; Sivappalasingham, M.; George, J. R.; Kilbourne, B.; Ou, C. Y.; Rapier, J.; Petent, J.; Schable, N.; Shaffer, N.; Smith, L.

In: Journal of Pediatrics, Vol. 130, No. 6, 1997, p. 890-897.

Research output: Contribution to journalArticle

Lambert, G, Thea, DM, Pliner, V, Steketee, RW, Abrams, EJ, Matheson, P, Thomas, PA, Greenberg, B, Brown, TM, Bamjl, M, Kalish, ML, Beatrice, S, Chiasson, MA, Debernardo, E, McVeigh, K, O'Donnell, R, Oleszko, W, Punsalang, A, Alford, T, Belmore, A, Betre, A, Capelli, M, Carrasquillo, N, Courtland, R, Cruz, N, Floyd, J, Foye-Sousou, V, Gonzales, C, Jackson, L, Jessop, DJ, Lopez, D, Macias, L, Ng, D, Weedon, J, Young, S, Zhang, ZR, Allen, M, Borkowsky, W, Hoover, W, Krasinski, K, Pollack, H, Champion, S, Freedland, C, Heagarty, M, Prince, P, Suarez, M, Chow, J, Kaul, A, Nachman, S, Shah, K, Ahmed, S, Agostin, E, Henriquez, R, Sacharzky, E, Losub, S, Brotman, R, Blanch, S, Brutus, J, Day, C, Hutson, D, Rhinehart, W, Simon, R, Turkell, V, Grimm, KT, Crane, M, Campbell, P, Davila, S, Dobrosyzcki, J, Grant, D, Hand, I, Harris, A, Nieves, M, Solomon, L, Steiner, A, Wiznia, A, Brooks, G, Nicholson, M, Mayers, MM, Naccarato, M, Schoenbaum, E, Sivappalasingham, M, George, JR, Kilbourne, B, Ou, CY, Rapier, J, Petent, J, Schable, N, Shaffer, N & Smith, L 1997, 'Effect of maternal CD4+ cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection', Journal of Pediatrics, vol. 130, no. 6, pp. 890-897. https://doi.org/10.1016/S0022-3476(97)70274-9
Lambert, G. ; Thea, D. M. ; Pliner, V. ; Steketee, R. W. ; Abrams, E. J. ; Matheson, P. ; Thomas, P. A. ; Greenberg, B. ; Brown, T. M. ; Bamjl, M. ; Kalish, M. L. ; Beatrice, S. ; Chiasson, M. A. ; Debernardo, E. ; McVeigh, K. ; O'Donnell, R. ; Oleszko, W. ; Punsalang, A. ; Alford, T. ; Belmore, A. ; Betre, A. ; Capelli, M. ; Carrasquillo, N. ; Courtland, R. ; Cruz, N. ; Floyd, J. ; Foye-Sousou, V. ; Gonzales, C. ; Jackson, L. ; Jessop, D. J. ; Lopez, D. ; Macias, L. ; Ng, D. ; Weedon, J. ; Young, S. ; Zhang, Z. R. ; Allen, M. ; Borkowsky, W. ; Hoover, W. ; Krasinski, K. ; Pollack, H. ; Champion, S. ; Freedland, C. ; Heagarty, M. ; Prince, P. ; Suarez, M. ; Chow, J. ; Kaul, A. ; Nachman, S. ; Shah, K. ; Ahmed, S. ; Agostin, E. ; Henriquez, R. ; Sacharzky, E. ; Losub, S. ; Brotman, R. ; Blanch, S. ; Brutus, J. ; Day, C. ; Hutson, D. ; Rhinehart, W. ; Simon, R. ; Turkell, V. ; Grimm, K. T. ; Crane, M. ; Campbell, P. ; Davila, S. ; Dobrosyzcki, J. ; Grant, D. ; Hand, I. ; Harris, A. ; Nieves, M. ; Solomon, L. ; Steiner, A. ; Wiznia, A. ; Brooks, G. ; Nicholson, M. ; Mayers, Marguerite M. ; Naccarato, M. ; Schoenbaum, Ellie ; Sivappalasingham, M. ; George, J. R. ; Kilbourne, B. ; Ou, C. Y. ; Rapier, J. ; Petent, J. ; Schable, N. ; Shaffer, N. ; Smith, L. / Effect of maternal CD4+ cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection. In: Journal of Pediatrics. 1997 ; Vol. 130, No. 6. pp. 890-897.
@article{bd9663fa805a46d18a7734c171ec606e,
title = "Effect of maternal CD4+ cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection",
abstract = "Among a cohort of 152 infants perinatally infected with human immunodeficiency virus type 1, and their mothers we correlated infant outcome with maternal CD4+ lymphocyte count and the presence of maternal acquired immunodeficiency syndrome near delivery. In a subset of 50 mother-infant pairs, we also correlated infant outcome with maternal quantitative viral burden as measured by the nucleic acid sequence based amplification system. We found that low maternal CD4+ cell count and high viral burden were associated with decreased time to category C disease or death in infants infected with human immunodeficiency virus type 1. In a multivariate analysis, high maternal viral load and maternal acquired immunodeficiency syndrome were independently associated with shorter time to category c disease or death in infants with human immunodeficiency virus type 1 infection. High viral load in pregnant women, independent of the presence of advanced maternal disease, appears to increase the risk of rapidly progressive disease in their infected offspring.",
author = "G. Lambert and Thea, {D. M.} and V. Pliner and Steketee, {R. W.} and Abrams, {E. J.} and P. Matheson and Thomas, {P. A.} and B. Greenberg and Brown, {T. M.} and M. Bamjl and Kalish, {M. L.} and S. Beatrice and Chiasson, {M. A.} and E. Debernardo and K. McVeigh and R. O'Donnell and W. Oleszko and A. Punsalang and T. Alford and A. Belmore and A. Betre and M. Capelli and N. Carrasquillo and R. Courtland and N. Cruz and J. Floyd and V. Foye-Sousou and C. Gonzales and L. Jackson and Jessop, {D. J.} and D. Lopez and L. Macias and D. Ng and J. Weedon and S. Young and Zhang, {Z. R.} and M. Allen and W. Borkowsky and W. Hoover and K. Krasinski and H. Pollack and S. Champion and C. Freedland and M. Heagarty and P. Prince and M. Suarez and J. Chow and A. Kaul and S. Nachman and K. Shah and S. Ahmed and E. Agostin and R. Henriquez and E. Sacharzky and S. Losub and R. Brotman and S. Blanch and J. Brutus and C. Day and D. Hutson and W. Rhinehart and R. Simon and V. Turkell and Grimm, {K. T.} and M. Crane and P. Campbell and S. Davila and J. Dobrosyzcki and D. Grant and I. Hand and A. Harris and M. Nieves and L. Solomon and A. Steiner and A. Wiznia and G. Brooks and M. Nicholson and Mayers, {Marguerite M.} and M. Naccarato and Ellie Schoenbaum and M. Sivappalasingham and George, {J. R.} and B. Kilbourne and Ou, {C. Y.} and J. Rapier and J. Petent and N. Schable and N. Shaffer and L. Smith",
year = "1997",
doi = "10.1016/S0022-3476(97)70274-9",
language = "English (US)",
volume = "130",
pages = "890--897",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Effect of maternal CD4+ cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection

AU - Lambert, G.

AU - Thea, D. M.

AU - Pliner, V.

AU - Steketee, R. W.

AU - Abrams, E. J.

AU - Matheson, P.

AU - Thomas, P. A.

AU - Greenberg, B.

AU - Brown, T. M.

AU - Bamjl, M.

AU - Kalish, M. L.

AU - Beatrice, S.

AU - Chiasson, M. A.

AU - Debernardo, E.

AU - McVeigh, K.

AU - O'Donnell, R.

AU - Oleszko, W.

AU - Punsalang, A.

AU - Alford, T.

AU - Belmore, A.

AU - Betre, A.

AU - Capelli, M.

AU - Carrasquillo, N.

AU - Courtland, R.

AU - Cruz, N.

AU - Floyd, J.

AU - Foye-Sousou, V.

AU - Gonzales, C.

AU - Jackson, L.

AU - Jessop, D. J.

AU - Lopez, D.

AU - Macias, L.

AU - Ng, D.

AU - Weedon, J.

AU - Young, S.

AU - Zhang, Z. R.

AU - Allen, M.

AU - Borkowsky, W.

AU - Hoover, W.

AU - Krasinski, K.

AU - Pollack, H.

AU - Champion, S.

AU - Freedland, C.

AU - Heagarty, M.

AU - Prince, P.

AU - Suarez, M.

AU - Chow, J.

AU - Kaul, A.

AU - Nachman, S.

AU - Shah, K.

AU - Ahmed, S.

AU - Agostin, E.

AU - Henriquez, R.

AU - Sacharzky, E.

AU - Losub, S.

AU - Brotman, R.

AU - Blanch, S.

AU - Brutus, J.

AU - Day, C.

AU - Hutson, D.

AU - Rhinehart, W.

AU - Simon, R.

AU - Turkell, V.

AU - Grimm, K. T.

AU - Crane, M.

AU - Campbell, P.

AU - Davila, S.

AU - Dobrosyzcki, J.

AU - Grant, D.

AU - Hand, I.

AU - Harris, A.

AU - Nieves, M.

AU - Solomon, L.

AU - Steiner, A.

AU - Wiznia, A.

AU - Brooks, G.

AU - Nicholson, M.

AU - Mayers, Marguerite M.

AU - Naccarato, M.

AU - Schoenbaum, Ellie

AU - Sivappalasingham, M.

AU - George, J. R.

AU - Kilbourne, B.

AU - Ou, C. Y.

AU - Rapier, J.

AU - Petent, J.

AU - Schable, N.

AU - Shaffer, N.

AU - Smith, L.

PY - 1997

Y1 - 1997

N2 - Among a cohort of 152 infants perinatally infected with human immunodeficiency virus type 1, and their mothers we correlated infant outcome with maternal CD4+ lymphocyte count and the presence of maternal acquired immunodeficiency syndrome near delivery. In a subset of 50 mother-infant pairs, we also correlated infant outcome with maternal quantitative viral burden as measured by the nucleic acid sequence based amplification system. We found that low maternal CD4+ cell count and high viral burden were associated with decreased time to category C disease or death in infants infected with human immunodeficiency virus type 1. In a multivariate analysis, high maternal viral load and maternal acquired immunodeficiency syndrome were independently associated with shorter time to category c disease or death in infants with human immunodeficiency virus type 1 infection. High viral load in pregnant women, independent of the presence of advanced maternal disease, appears to increase the risk of rapidly progressive disease in their infected offspring.

AB - Among a cohort of 152 infants perinatally infected with human immunodeficiency virus type 1, and their mothers we correlated infant outcome with maternal CD4+ lymphocyte count and the presence of maternal acquired immunodeficiency syndrome near delivery. In a subset of 50 mother-infant pairs, we also correlated infant outcome with maternal quantitative viral burden as measured by the nucleic acid sequence based amplification system. We found that low maternal CD4+ cell count and high viral burden were associated with decreased time to category C disease or death in infants infected with human immunodeficiency virus type 1. In a multivariate analysis, high maternal viral load and maternal acquired immunodeficiency syndrome were independently associated with shorter time to category c disease or death in infants with human immunodeficiency virus type 1 infection. High viral load in pregnant women, independent of the presence of advanced maternal disease, appears to increase the risk of rapidly progressive disease in their infected offspring.

UR - http://www.scopus.com/inward/record.url?scp=0030665547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030665547&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(97)70274-9

DO - 10.1016/S0022-3476(97)70274-9

M3 - Article

C2 - 9202610

AN - SCOPUS:0030665547

VL - 130

SP - 890

EP - 897

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 6

ER -