Effect of long term low-fat dietary intervention on change in hemostatic factors: Results from the Women's Health Initiative

S. N. Rajpathak, X. Xue, S. Wassertheil-Smoller, L. Van Horn, L. Snetselaar, L. W. Martin, T. E. Rohan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Low-fat diet may play a role in prevention of cardiovascular disease (CVD) by altering the levels of hemostatic factors. There are yet limited data on the effects of low-fat diet on the circulating levels of these factors and existing studies are limited by small sample size and short duration of follow-up. We conducted an analysis in a subset of women (active arm = 723; control arm = 1036) within the Women's Health Initiative Dietary Modification Trial to investigate the long term effect of a low-fat diet on circulating levels of fibrinogen, factor VII concentration and factor VII activity among postmenopausal women aged 50-79 years. Using linear mixed effects model with random intercept and data from three follow-up visits (years 1, 3 and 6) we evaluated the change in each factor over time. Overall, the changes in these factors were small (less than 5%) in both the arms of the trials at the end of intervention and there was no significant difference in mean change between the two arms. Our results indicate that the low-fat dietary intervention was not associated with significant changes in hemostatic factors among postmenopausal women.

Original languageEnglish (US)
Pages (from-to)337-339
Number of pages3
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume22
Issue number4
DOIs
StatePublished - Apr 1 2012

Keywords

  • Hemostatic factors
  • Low-fat diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

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