Effect of long term low-fat dietary intervention on change in hemostatic factors

Results from the Women's Health Initiative

S. N. Rajpathak, Xiaonan (Nan) Xue, S. Wassertheil-Smoller, L. Van Horn, L. Snetselaar, L. W. Martin, Thomas E. Rohan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Low-fat diet may play a role in prevention of cardiovascular disease (CVD) by altering the levels of hemostatic factors. There are yet limited data on the effects of low-fat diet on the circulating levels of these factors and existing studies are limited by small sample size and short duration of follow-up. We conducted an analysis in a subset of women (active arm = 723; control arm = 1036) within the Women's Health Initiative Dietary Modification Trial to investigate the long term effect of a low-fat diet on circulating levels of fibrinogen, factor VII concentration and factor VII activity among postmenopausal women aged 50-79 years. Using linear mixed effects model with random intercept and data from three follow-up visits (years 1, 3 and 6) we evaluated the change in each factor over time. Overall, the changes in these factors were small (less than 5%) in both the arms of the trials at the end of intervention and there was no significant difference in mean change between the two arms. Our results indicate that the low-fat dietary intervention was not associated with significant changes in hemostatic factors among postmenopausal women.

Original languageEnglish (US)
Pages (from-to)337-339
Number of pages3
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume22
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Fat-Restricted Diet
Dietary Fats
Women's Health
Hemostatics
Factor VII
Diet Therapy
Sample Size
Fibrinogen
Cardiovascular Diseases

Keywords

  • Hemostatic factors
  • Low-fat diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Effect of long term low-fat dietary intervention on change in hemostatic factors : Results from the Women's Health Initiative. / Rajpathak, S. N.; Xue, Xiaonan (Nan); Wassertheil-Smoller, S.; Van Horn, L.; Snetselaar, L.; Martin, L. W.; Rohan, Thomas E.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 22, No. 4, 04.2012, p. 337-339.

Research output: Contribution to journalArticle

@article{dec84361ecdd421f83d55542bdc62a0d,
title = "Effect of long term low-fat dietary intervention on change in hemostatic factors: Results from the Women's Health Initiative",
abstract = "Low-fat diet may play a role in prevention of cardiovascular disease (CVD) by altering the levels of hemostatic factors. There are yet limited data on the effects of low-fat diet on the circulating levels of these factors and existing studies are limited by small sample size and short duration of follow-up. We conducted an analysis in a subset of women (active arm = 723; control arm = 1036) within the Women's Health Initiative Dietary Modification Trial to investigate the long term effect of a low-fat diet on circulating levels of fibrinogen, factor VII concentration and factor VII activity among postmenopausal women aged 50-79 years. Using linear mixed effects model with random intercept and data from three follow-up visits (years 1, 3 and 6) we evaluated the change in each factor over time. Overall, the changes in these factors were small (less than 5{\%}) in both the arms of the trials at the end of intervention and there was no significant difference in mean change between the two arms. Our results indicate that the low-fat dietary intervention was not associated with significant changes in hemostatic factors among postmenopausal women.",
keywords = "Hemostatic factors, Low-fat diet",
author = "Rajpathak, {S. N.} and Xue, {Xiaonan (Nan)} and S. Wassertheil-Smoller and {Van Horn}, L. and L. Snetselaar and Martin, {L. W.} and Rohan, {Thomas E.}",
year = "2012",
month = "4",
doi = "10.1016/j.numecd.2010.07.002",
language = "English (US)",
volume = "22",
pages = "337--339",
journal = "Nutrition, Metabolism and Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Effect of long term low-fat dietary intervention on change in hemostatic factors

T2 - Results from the Women's Health Initiative

AU - Rajpathak, S. N.

AU - Xue, Xiaonan (Nan)

AU - Wassertheil-Smoller, S.

AU - Van Horn, L.

AU - Snetselaar, L.

AU - Martin, L. W.

AU - Rohan, Thomas E.

PY - 2012/4

Y1 - 2012/4

N2 - Low-fat diet may play a role in prevention of cardiovascular disease (CVD) by altering the levels of hemostatic factors. There are yet limited data on the effects of low-fat diet on the circulating levels of these factors and existing studies are limited by small sample size and short duration of follow-up. We conducted an analysis in a subset of women (active arm = 723; control arm = 1036) within the Women's Health Initiative Dietary Modification Trial to investigate the long term effect of a low-fat diet on circulating levels of fibrinogen, factor VII concentration and factor VII activity among postmenopausal women aged 50-79 years. Using linear mixed effects model with random intercept and data from three follow-up visits (years 1, 3 and 6) we evaluated the change in each factor over time. Overall, the changes in these factors were small (less than 5%) in both the arms of the trials at the end of intervention and there was no significant difference in mean change between the two arms. Our results indicate that the low-fat dietary intervention was not associated with significant changes in hemostatic factors among postmenopausal women.

AB - Low-fat diet may play a role in prevention of cardiovascular disease (CVD) by altering the levels of hemostatic factors. There are yet limited data on the effects of low-fat diet on the circulating levels of these factors and existing studies are limited by small sample size and short duration of follow-up. We conducted an analysis in a subset of women (active arm = 723; control arm = 1036) within the Women's Health Initiative Dietary Modification Trial to investigate the long term effect of a low-fat diet on circulating levels of fibrinogen, factor VII concentration and factor VII activity among postmenopausal women aged 50-79 years. Using linear mixed effects model with random intercept and data from three follow-up visits (years 1, 3 and 6) we evaluated the change in each factor over time. Overall, the changes in these factors were small (less than 5%) in both the arms of the trials at the end of intervention and there was no significant difference in mean change between the two arms. Our results indicate that the low-fat dietary intervention was not associated with significant changes in hemostatic factors among postmenopausal women.

KW - Hemostatic factors

KW - Low-fat diet

UR - http://www.scopus.com/inward/record.url?scp=84858409293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858409293&partnerID=8YFLogxK

U2 - 10.1016/j.numecd.2010.07.002

DO - 10.1016/j.numecd.2010.07.002

M3 - Article

VL - 22

SP - 337

EP - 339

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

IS - 4

ER -