Effect of Ku80 deficiency on mutation frequencies and spectra at a lacZ reporter locus in mouse tissues and cells

Agriculture & Biology

• mutation rate 100%
• DNA damage 67%
• loci 56%
• mice 52%
• genome 50%
• tissues 40%
• fibroblasts 40%
• liver 40%
• cell senescence 33%
• mutation 31%
• spontaneous mutation 30%
• sequence deletion 30%
• cells 29%
• young adults 24%
• cultured cells 21%
• hydrogen peroxide 20%
• spleen 19%
• adverse effects 18%
• plasmids 17%
• brain 16%
• mutants 13%
• DNA 11%

Medicine & Life Sciences

• Mutation Rate 97%
• Genome 62%
• Premature Aging 61%
• DNA Damage 59%
• Point Mutation 44%
• Liver 35%
• Fibroblasts 34%
• Sequence Deletion 26%
• Double-Stranded DNA Breaks 26%
• Bleomycin 26%
• Mutation 25%
• Cellular Senescence 25%
• Hydrogen Peroxide 22%
• Cultured Cells 19%
• Young Adult 18%
• Plasmids 18%
• Spleen 17%
• Animals 11%
• Brain 11%
• Therapeutics 7%

Chemical Compounds

• Mutation 77%
• Bleomycin 20%
• Hydrogen Peroxide 11%
• Time 5%