Effect of Jinfu Kang to experimental precancerous colon lesions and urinary metabolites in rat

Yin Ping Qiu, Ming Ming Su, Da Zheng Wu, Ai Hua Zhao, Yu Min Liu, Wei Jia

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Objective: To profile urinary metabolite variations from 1, 2-dimethylhydrazine (DMH)-induced precancerous colon rats, Jinfu Kang treated rats and healthy controls. Method: We used ethyl chloroformate derivatization and gas chromatographymass spectrometry (GC-MS) based metabonomic method to analyze rat urines. Result: The time-dependent variations of metabolite profile showed a progressive deviation of the metabolism in die model group from the initial pattern over time and a systemic recovery of the metabolism in the treatment group, which is consistent with the histological results. The in-depth analysis indicated that the disorder of tricarboxylic acid cycle (TCA), tryptophan metabolism, polyamine metabolism and gut flora structure were associated with DMH intervention. Conclusion: Metabolic study revealed that Jinfu Kang can effectively reverse metabolic departures in DMH-induced precancerous colon rat, which is consistent with pathological results.

Original languageEnglish (US)
Pages (from-to)2653-2657
Number of pages5
JournalZhongguo Zhongyao Zazhi
Volume33
Issue number22
StatePublished - Nov 1 2008
Externally publishedYes

Keywords

  • 1, 2-dimethylhydrazine (DMH)
  • Jinfu Kang
  • Pattern recognize
  • Precancerous colon; metabonomics

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Complementary and alternative medicine
  • Pharmacology (medical)

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    Qiu, Y. P., Su, M. M., Wu, D. Z., Zhao, A. H., Liu, Y. M., & Jia, W. (2008). Effect of Jinfu Kang to experimental precancerous colon lesions and urinary metabolites in rat. Zhongguo Zhongyao Zazhi, 33(22), 2653-2657.