Abstract
Objective: To profile urinary metabolite variations from 1, 2-dimethylhydrazine (DMH)-induced precancerous colon rats, Jinfu Kang treated rats and healthy controls. Method: We used ethyl chloroformate derivatization and gas chromatographymass spectrometry (GC-MS) based metabonomic method to analyze rat urines. Result: The time-dependent variations of metabolite profile showed a progressive deviation of the metabolism in die model group from the initial pattern over time and a systemic recovery of the metabolism in the treatment group, which is consistent with the histological results. The in-depth analysis indicated that the disorder of tricarboxylic acid cycle (TCA), tryptophan metabolism, polyamine metabolism and gut flora structure were associated with DMH intervention. Conclusion: Metabolic study revealed that Jinfu Kang can effectively reverse metabolic departures in DMH-induced precancerous colon rat, which is consistent with pathological results.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2653-2657 |
| Number of pages | 5 |
| Journal | Zhongguo Zhongyao Zazhi |
| Volume | 33 |
| Issue number | 22 |
| State | Published - Nov 2008 |
| Externally published | Yes |
Keywords
- 1, 2-dimethylhydrazine (DMH)
- Jinfu Kang
- Pattern recognize
- Precancerous colon; metabonomics
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Complementary and alternative medicine
- Pharmacology (medical)