Effect of immune mechanisms on the pharmacokinetics and organ distribution of Cryptococcal polysaccharide

Nikoletta Lendvai, Arturo Casadevall, Zhenglu Liang, David L. Goldman, Jean Mukherjee, Lionel Zuckier

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Cryptococcus neoformans is an encapsulated opportunistic fungus that can cause chronic infections accompanied by high tissue levels of capsular polysaccharide (CPS). CPS or its major component, glucuronoxylomannan (GXM), was administered to mice, and whole-body and tissue levels were measured. The role of monoclonal antibody (MAb), complement, and CD4 T cells in GXM clearance was also examined. These studies demonstrate that CPS is cleared from the blood within days but is retained in the body for weeks; that MAbs of all isotypes examined promote GXM clearance; that MAb-mediated GXM deposition in liver, but not in spleen, is Fc-dependent; that complement enhances IgM-mediated GXM sequestration in liver but not spleen; and that CD4 T cells are not necessary for serum GXM clearance. The results have important implications for the eventual use of MAbs in treatment of cryptococcosis.

Original languageEnglish (US)
Pages (from-to)1647-1659
Number of pages13
JournalJournal of Infectious Diseases
Volume177
Issue number6
StatePublished - 1998
Externally publishedYes

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Pharmacokinetics
Polysaccharides
Spleen
Monoclonal Antibodies
T-Lymphocytes
Cryptococcosis
Cryptococcus neoformans
Liver
Immunoglobulin M
glucuronoxylomannan
cryptococcal polysaccharide
Fungi
Infection
Serum

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Effect of immune mechanisms on the pharmacokinetics and organ distribution of Cryptococcal polysaccharide. / Lendvai, Nikoletta; Casadevall, Arturo; Liang, Zhenglu; Goldman, David L.; Mukherjee, Jean; Zuckier, Lionel.

In: Journal of Infectious Diseases, Vol. 177, No. 6, 1998, p. 1647-1659.

Research output: Contribution to journalArticle

Lendvai, N, Casadevall, A, Liang, Z, Goldman, DL, Mukherjee, J & Zuckier, L 1998, 'Effect of immune mechanisms on the pharmacokinetics and organ distribution of Cryptococcal polysaccharide', Journal of Infectious Diseases, vol. 177, no. 6, pp. 1647-1659.
Lendvai, Nikoletta ; Casadevall, Arturo ; Liang, Zhenglu ; Goldman, David L. ; Mukherjee, Jean ; Zuckier, Lionel. / Effect of immune mechanisms on the pharmacokinetics and organ distribution of Cryptococcal polysaccharide. In: Journal of Infectious Diseases. 1998 ; Vol. 177, No. 6. pp. 1647-1659.
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