Effect of highly active antiretroviral therapy on the incidence of HIV- associated malignancies at an Urban Medical Center

Joseph A. Sparano, Kanchana Anand, Jigna Desai, Robin J. Mitnick, Gary E. Kalkut, Lawrence H. Hanau

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The widespread use of highly active antiretroviral therapy (HAART) since 1996 has led to a substantial decline in morbidity and mortality in patients infected with HIV, although its effect on the incidence of HIV-associated malignancies is unknown. We retrospectively reviewed the annual number of outpatient visits to our HIV clinic, inpatient admissions for HIV disease, and first admissions for patients with cancer and HIV disease at our center between 1990 and 1997. Between 1990 and 1995, there was a progressive increase in the annual number of admissions for HIV disease and HIV- associated cancers that paralleled the increasing HIV clinic volume. In 1997, however, the annual number of first admissions for Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma compared with 1995 decreased by 36% and 63%, respectively, despite a continued increase in the annual number of HIV clinic visits. Similar declines were also noted in the number of new cases of biopsy-confirmed KS and primary central nervous system (CNS) lymphoma. In contrast, there was no decrease in the number of first admissions for patients with HIV infection and other cancers not typically associated with HIV infection. These findings suggest a declining incidence of HIV-associated malignancies since the introduction of HAART.

Original languageEnglish (US)
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume21
Issue number4 SUPPL.
StatePublished - Aug 1 1999

Fingerprint

Highly Active Antiretroviral Therapy
HIV
Incidence
Neoplasms
Kaposi's Sarcoma
Patient Admission
HIV Infections
Ambulatory Care
Non-Hodgkin's Lymphoma
Inpatients
Lymphoma
Outpatients
Central Nervous System
Morbidity
Biopsy
Mortality

Keywords

  • AIDS
  • Cancer
  • HIV infection
  • Kaposi's sarcoma
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

Effect of highly active antiretroviral therapy on the incidence of HIV- associated malignancies at an Urban Medical Center. / Sparano, Joseph A.; Anand, Kanchana; Desai, Jigna; Mitnick, Robin J.; Kalkut, Gary E.; Hanau, Lawrence H.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 21, No. 4 SUPPL., 01.08.1999.

Research output: Contribution to journalArticle

@article{b98bea802f2b4e7883554d153faacf44,
title = "Effect of highly active antiretroviral therapy on the incidence of HIV- associated malignancies at an Urban Medical Center",
abstract = "The widespread use of highly active antiretroviral therapy (HAART) since 1996 has led to a substantial decline in morbidity and mortality in patients infected with HIV, although its effect on the incidence of HIV-associated malignancies is unknown. We retrospectively reviewed the annual number of outpatient visits to our HIV clinic, inpatient admissions for HIV disease, and first admissions for patients with cancer and HIV disease at our center between 1990 and 1997. Between 1990 and 1995, there was a progressive increase in the annual number of admissions for HIV disease and HIV- associated cancers that paralleled the increasing HIV clinic volume. In 1997, however, the annual number of first admissions for Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma compared with 1995 decreased by 36{\%} and 63{\%}, respectively, despite a continued increase in the annual number of HIV clinic visits. Similar declines were also noted in the number of new cases of biopsy-confirmed KS and primary central nervous system (CNS) lymphoma. In contrast, there was no decrease in the number of first admissions for patients with HIV infection and other cancers not typically associated with HIV infection. These findings suggest a declining incidence of HIV-associated malignancies since the introduction of HAART.",
keywords = "AIDS, Cancer, HIV infection, Kaposi's sarcoma, Non-Hodgkin's lymphoma",
author = "Sparano, {Joseph A.} and Kanchana Anand and Jigna Desai and Mitnick, {Robin J.} and Kalkut, {Gary E.} and Hanau, {Lawrence H.}",
year = "1999",
month = "8",
day = "1",
language = "English (US)",
volume = "21",
journal = "Journal of Acquired Immune Deficiency Syndromes",
issn = "1525-4135",
publisher = "Lippincott Williams and Wilkins",
number = "4 SUPPL.",

}

TY - JOUR

T1 - Effect of highly active antiretroviral therapy on the incidence of HIV- associated malignancies at an Urban Medical Center

AU - Sparano, Joseph A.

AU - Anand, Kanchana

AU - Desai, Jigna

AU - Mitnick, Robin J.

AU - Kalkut, Gary E.

AU - Hanau, Lawrence H.

PY - 1999/8/1

Y1 - 1999/8/1

N2 - The widespread use of highly active antiretroviral therapy (HAART) since 1996 has led to a substantial decline in morbidity and mortality in patients infected with HIV, although its effect on the incidence of HIV-associated malignancies is unknown. We retrospectively reviewed the annual number of outpatient visits to our HIV clinic, inpatient admissions for HIV disease, and first admissions for patients with cancer and HIV disease at our center between 1990 and 1997. Between 1990 and 1995, there was a progressive increase in the annual number of admissions for HIV disease and HIV- associated cancers that paralleled the increasing HIV clinic volume. In 1997, however, the annual number of first admissions for Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma compared with 1995 decreased by 36% and 63%, respectively, despite a continued increase in the annual number of HIV clinic visits. Similar declines were also noted in the number of new cases of biopsy-confirmed KS and primary central nervous system (CNS) lymphoma. In contrast, there was no decrease in the number of first admissions for patients with HIV infection and other cancers not typically associated with HIV infection. These findings suggest a declining incidence of HIV-associated malignancies since the introduction of HAART.

AB - The widespread use of highly active antiretroviral therapy (HAART) since 1996 has led to a substantial decline in morbidity and mortality in patients infected with HIV, although its effect on the incidence of HIV-associated malignancies is unknown. We retrospectively reviewed the annual number of outpatient visits to our HIV clinic, inpatient admissions for HIV disease, and first admissions for patients with cancer and HIV disease at our center between 1990 and 1997. Between 1990 and 1995, there was a progressive increase in the annual number of admissions for HIV disease and HIV- associated cancers that paralleled the increasing HIV clinic volume. In 1997, however, the annual number of first admissions for Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma compared with 1995 decreased by 36% and 63%, respectively, despite a continued increase in the annual number of HIV clinic visits. Similar declines were also noted in the number of new cases of biopsy-confirmed KS and primary central nervous system (CNS) lymphoma. In contrast, there was no decrease in the number of first admissions for patients with HIV infection and other cancers not typically associated with HIV infection. These findings suggest a declining incidence of HIV-associated malignancies since the introduction of HAART.

KW - AIDS

KW - Cancer

KW - HIV infection

KW - Kaposi's sarcoma

KW - Non-Hodgkin's lymphoma

UR - http://www.scopus.com/inward/record.url?scp=0033178773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033178773&partnerID=8YFLogxK

M3 - Article

VL - 21

JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

SN - 1525-4135

IS - 4 SUPPL.

ER -