Effect of high-dose corticosteroid therapy on blood flow, evoked potentials, and extracellular calcium in experimental spinal injury

W. Young, Eugene S. Flamm

Research output: Contribution to journalArticle

236 Citations (Scopus)

Abstract

High-dose methylprednisolone (15 to 30 mg/kg), administered 45 minutes after severe contusion injury (400 gm-cm) to cat spinal cords, rapidly reverses the typical posttraumatic ischemia that occurs in spinal injuries. White matter blood flow improves despite the systemic hypotension associated with bolus intravenous injections of such massive corticosteroid doses. In addition, this treatment facilitates extracellular calcium ionic recovery in contused spinal cords, and salvages evoked potential activity that is lost in untreated cats. These data suggest that high-dose corticosteroid treatment causes local vasodilation of spinal cord blood vessels. The consequent blood flow increase may account for the beneficial effects of high-dose corticosteroid treatment on both functional recovery and histopathological appearance of injured spinal cords.

Original languageEnglish (US)
Pages (from-to)667-673
Number of pages7
JournalJournal of Neurosurgery
Volume57
Issue number5
StatePublished - 1982
Externally publishedYes

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Spinal Injuries
Evoked Potentials
Spinal Cord
Adrenal Cortex Hormones
Calcium
Contusions
Cats
Methylprednisolone
Therapeutics
Fetal Blood
Vasodilation
Intravenous Injections
Hypotension
Blood Vessels
Ischemia
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

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AU - Flamm, Eugene S.

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AB - High-dose methylprednisolone (15 to 30 mg/kg), administered 45 minutes after severe contusion injury (400 gm-cm) to cat spinal cords, rapidly reverses the typical posttraumatic ischemia that occurs in spinal injuries. White matter blood flow improves despite the systemic hypotension associated with bolus intravenous injections of such massive corticosteroid doses. In addition, this treatment facilitates extracellular calcium ionic recovery in contused spinal cords, and salvages evoked potential activity that is lost in untreated cats. These data suggest that high-dose corticosteroid treatment causes local vasodilation of spinal cord blood vessels. The consequent blood flow increase may account for the beneficial effects of high-dose corticosteroid treatment on both functional recovery and histopathological appearance of injured spinal cords.

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