Effect of Heparin on Blood Vascular Endothelial Growth Factor Levels in Patients With ST-Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Małgorzata Pyda, Katarzyna Korybalska, Krzysztof Ksia̧zek, Stefan Grajek, Magdalena Łanocha, Maciej Lesiak, Justyna Wiśniewska-Elnur, Anna Olasińska, Andrzej Brȩborowicz, Andrzej Cieśliński, Janusz Witowski

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

It has been demonstrated that high blood vascular endothelial growth factor (VEGF) levels in patients with myocardial infarction decrease rapidly after reperfusion, possibly in response to heparin administration. We measured serum VEGF concentration before and after heparin infusion in 105 patients with ST-elevation acute myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). Serum VEGF concentration in patients with STEMI was significantly higher than in healthy controls. After PCI, the concentration of VEGF decreased by approximately 70%, with the greatest decrease seen in patients with the highest initial VEGF levels. To determine whether heparin could decrease VEGF concentration by sequestering VEGF in the endothelium, a fixed dose of recombinant VEGF was incubated for 40 minutes with EA.hy926 endothelial cells in vitro. Recovery of VEGF from medium after culture was decreased by up to 15% with increasing doses of heparin. Concentration of VEGF did not change in the absence of heparin and/or endothelial cells. In conclusion, these results suggest that a rapid decrease in blood VEGF after PCI may be related to the administration of heparin, which binds simultaneously to VEGF and endothelial cells.

Original languageEnglish (US)
Pages (from-to)902-905
Number of pages4
JournalAmerican Journal of Cardiology
Volume98
Issue number7
DOIs
StatePublished - Oct 1 2006
Externally publishedYes

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Percutaneous Coronary Intervention
Vascular Endothelial Growth Factor A
Heparin
Endothelial Cells
ST Elevation Myocardial Infarction
Serum
Reperfusion
Endothelium
Culture Media
Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of Heparin on Blood Vascular Endothelial Growth Factor Levels in Patients With ST-Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. / Pyda, Małgorzata; Korybalska, Katarzyna; Ksia̧zek, Krzysztof; Grajek, Stefan; Łanocha, Magdalena; Lesiak, Maciej; Wiśniewska-Elnur, Justyna; Olasińska, Anna; Brȩborowicz, Andrzej; Cieśliński, Andrzej; Witowski, Janusz.

In: American Journal of Cardiology, Vol. 98, No. 7, 01.10.2006, p. 902-905.

Research output: Contribution to journalArticle

Pyda, M, Korybalska, K, Ksia̧zek, K, Grajek, S, Łanocha, M, Lesiak, M, Wiśniewska-Elnur, J, Olasińska, A, Brȩborowicz, A, Cieśliński, A & Witowski, J 2006, 'Effect of Heparin on Blood Vascular Endothelial Growth Factor Levels in Patients With ST-Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention', American Journal of Cardiology, vol. 98, no. 7, pp. 902-905. https://doi.org/10.1016/j.amjcard.2006.04.028
Pyda, Małgorzata ; Korybalska, Katarzyna ; Ksia̧zek, Krzysztof ; Grajek, Stefan ; Łanocha, Magdalena ; Lesiak, Maciej ; Wiśniewska-Elnur, Justyna ; Olasińska, Anna ; Brȩborowicz, Andrzej ; Cieśliński, Andrzej ; Witowski, Janusz. / Effect of Heparin on Blood Vascular Endothelial Growth Factor Levels in Patients With ST-Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. In: American Journal of Cardiology. 2006 ; Vol. 98, No. 7. pp. 902-905.
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