Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders: A pilot study

Monte S. Buchsbaum, Eric Hollander, M. Mehmet Haznedar, Cheuk Tang, Jacqueline Spiegel-Cohen, Tse Chung Wei, Andrea Solimando, Bradley R. Buchsbaum, Diana Robins, Carol Bienstock, Charles Cartwright, Serge Mosovich

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

The regional metabolic effects of fluoxetine were examined in patients with autism spectrum disorders. Six adult patients with DSM-IV and Autism Diagnostic Interview (ADI) diagnoses of autism (n = 5) and Asperger's syndrome (n = 1), entered a 16-wk placebo-controlled cross-over trial of fluoxetine. The patients received 18F-deoxyglucose positron emission tomography with co-registered magnetic resonance imaging at baseline and at the end of the period of fluoxetine administration. After treatment, the patients showed significant improvement on the scores of the Yale - Brown Obsessive - Compulsive Scale - Obsessions subscale and the Hamilton Anxiety Scale; Clinical Global Impressions - Autism scores showed 3 of the patients much improved and 3 unchanged. Relative metabolic rates were significantly higher in the right frontal lobe following fluoxetine, especially in the anterior cingulate gyrus and the orbitofrontal cortex. Patients with higher metabolic rates in the medial frontal region and anterior cingulate when unmedicated were more likely to respond favourably to fluoxetine. These results are consistent with those in depression indicating that higher cingulate gyrus metabolic rates at baseline predict SRI response.

Original languageEnglish (US)
Pages (from-to)119-125
Number of pages7
JournalInternational Journal of Neuropsychopharmacology
Volume4
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Fluoxetine
Autistic Disorder
Gyrus Cinguli
Asperger Syndrome
Obsessive Behavior
Deoxyglucose
Frontal Lobe
Prefrontal Cortex
Diagnostic and Statistical Manual of Mental Disorders
Positron-Emission Tomography
Cross-Over Studies
Anxiety
Placebos
Magnetic Resonance Imaging
Interviews
Depression

Keywords

  • Asperger's syndrome
  • Autism
  • Cingulate gyrus
  • Magnetic resonance imaging
  • Orbitofrontal cortex
  • Positron emission tomography
  • Selective serotonin reuptake inhibitor

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders : A pilot study. / Buchsbaum, Monte S.; Hollander, Eric; Mehmet Haznedar, M.; Tang, Cheuk; Spiegel-Cohen, Jacqueline; Wei, Tse Chung; Solimando, Andrea; Buchsbaum, Bradley R.; Robins, Diana; Bienstock, Carol; Cartwright, Charles; Mosovich, Serge.

In: International Journal of Neuropsychopharmacology, Vol. 4, No. 2, 2001, p. 119-125.

Research output: Contribution to journalArticle

Buchsbaum, MS, Hollander, E, Mehmet Haznedar, M, Tang, C, Spiegel-Cohen, J, Wei, TC, Solimando, A, Buchsbaum, BR, Robins, D, Bienstock, C, Cartwright, C & Mosovich, S 2001, 'Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders: A pilot study', International Journal of Neuropsychopharmacology, vol. 4, no. 2, pp. 119-125. https://doi.org/10.1017/S1461145701002280
Buchsbaum, Monte S. ; Hollander, Eric ; Mehmet Haznedar, M. ; Tang, Cheuk ; Spiegel-Cohen, Jacqueline ; Wei, Tse Chung ; Solimando, Andrea ; Buchsbaum, Bradley R. ; Robins, Diana ; Bienstock, Carol ; Cartwright, Charles ; Mosovich, Serge. / Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders : A pilot study. In: International Journal of Neuropsychopharmacology. 2001 ; Vol. 4, No. 2. pp. 119-125.
@article{5c8c175187f644a3b117ffd77b4bdf54,
title = "Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders: A pilot study",
abstract = "The regional metabolic effects of fluoxetine were examined in patients with autism spectrum disorders. Six adult patients with DSM-IV and Autism Diagnostic Interview (ADI) diagnoses of autism (n = 5) and Asperger's syndrome (n = 1), entered a 16-wk placebo-controlled cross-over trial of fluoxetine. The patients received 18F-deoxyglucose positron emission tomography with co-registered magnetic resonance imaging at baseline and at the end of the period of fluoxetine administration. After treatment, the patients showed significant improvement on the scores of the Yale - Brown Obsessive - Compulsive Scale - Obsessions subscale and the Hamilton Anxiety Scale; Clinical Global Impressions - Autism scores showed 3 of the patients much improved and 3 unchanged. Relative metabolic rates were significantly higher in the right frontal lobe following fluoxetine, especially in the anterior cingulate gyrus and the orbitofrontal cortex. Patients with higher metabolic rates in the medial frontal region and anterior cingulate when unmedicated were more likely to respond favourably to fluoxetine. These results are consistent with those in depression indicating that higher cingulate gyrus metabolic rates at baseline predict SRI response.",
keywords = "Asperger's syndrome, Autism, Cingulate gyrus, Magnetic resonance imaging, Orbitofrontal cortex, Positron emission tomography, Selective serotonin reuptake inhibitor",
author = "Buchsbaum, {Monte S.} and Eric Hollander and {Mehmet Haznedar}, M. and Cheuk Tang and Jacqueline Spiegel-Cohen and Wei, {Tse Chung} and Andrea Solimando and Buchsbaum, {Bradley R.} and Diana Robins and Carol Bienstock and Charles Cartwright and Serge Mosovich",
year = "2001",
doi = "10.1017/S1461145701002280",
language = "English (US)",
volume = "4",
pages = "119--125",
journal = "International Journal of Neuropsychopharmacology",
issn = "1461-1457",
publisher = "Cambridge University Press",
number = "2",

}

TY - JOUR

T1 - Effect of fluoxetine on regional cerebral metabolism in autistic spectrum disorders

T2 - A pilot study

AU - Buchsbaum, Monte S.

AU - Hollander, Eric

AU - Mehmet Haznedar, M.

AU - Tang, Cheuk

AU - Spiegel-Cohen, Jacqueline

AU - Wei, Tse Chung

AU - Solimando, Andrea

AU - Buchsbaum, Bradley R.

AU - Robins, Diana

AU - Bienstock, Carol

AU - Cartwright, Charles

AU - Mosovich, Serge

PY - 2001

Y1 - 2001

N2 - The regional metabolic effects of fluoxetine were examined in patients with autism spectrum disorders. Six adult patients with DSM-IV and Autism Diagnostic Interview (ADI) diagnoses of autism (n = 5) and Asperger's syndrome (n = 1), entered a 16-wk placebo-controlled cross-over trial of fluoxetine. The patients received 18F-deoxyglucose positron emission tomography with co-registered magnetic resonance imaging at baseline and at the end of the period of fluoxetine administration. After treatment, the patients showed significant improvement on the scores of the Yale - Brown Obsessive - Compulsive Scale - Obsessions subscale and the Hamilton Anxiety Scale; Clinical Global Impressions - Autism scores showed 3 of the patients much improved and 3 unchanged. Relative metabolic rates were significantly higher in the right frontal lobe following fluoxetine, especially in the anterior cingulate gyrus and the orbitofrontal cortex. Patients with higher metabolic rates in the medial frontal region and anterior cingulate when unmedicated were more likely to respond favourably to fluoxetine. These results are consistent with those in depression indicating that higher cingulate gyrus metabolic rates at baseline predict SRI response.

AB - The regional metabolic effects of fluoxetine were examined in patients with autism spectrum disorders. Six adult patients with DSM-IV and Autism Diagnostic Interview (ADI) diagnoses of autism (n = 5) and Asperger's syndrome (n = 1), entered a 16-wk placebo-controlled cross-over trial of fluoxetine. The patients received 18F-deoxyglucose positron emission tomography with co-registered magnetic resonance imaging at baseline and at the end of the period of fluoxetine administration. After treatment, the patients showed significant improvement on the scores of the Yale - Brown Obsessive - Compulsive Scale - Obsessions subscale and the Hamilton Anxiety Scale; Clinical Global Impressions - Autism scores showed 3 of the patients much improved and 3 unchanged. Relative metabolic rates were significantly higher in the right frontal lobe following fluoxetine, especially in the anterior cingulate gyrus and the orbitofrontal cortex. Patients with higher metabolic rates in the medial frontal region and anterior cingulate when unmedicated were more likely to respond favourably to fluoxetine. These results are consistent with those in depression indicating that higher cingulate gyrus metabolic rates at baseline predict SRI response.

KW - Asperger's syndrome

KW - Autism

KW - Cingulate gyrus

KW - Magnetic resonance imaging

KW - Orbitofrontal cortex

KW - Positron emission tomography

KW - Selective serotonin reuptake inhibitor

UR - http://www.scopus.com/inward/record.url?scp=0034955752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034955752&partnerID=8YFLogxK

U2 - 10.1017/S1461145701002280

DO - 10.1017/S1461145701002280

M3 - Article

C2 - 11466160

AN - SCOPUS:0034955752

VL - 4

SP - 119

EP - 125

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

SN - 1461-1457

IS - 2

ER -