Effect of fluoxetine on brain oxidative stress, neuronal damage and behavioural induced in the olfactory bulbectomy model of depression

Isaac Túnez; Francisco J. Medina; Ignacio Jimena; María Del C. Muñoz; José Peña; Inmaculada Tasset; Pedro Montilla

doi:10.2174/157018007784620013

Effect of fluoxetine on brain oxidative stress, neuronal damage and behavioural induced in the olfactory bulbectomy model of depression

Isaac Túnez, Francisco J. Medina, Ignacio Jimena, María Del C. Muñoz, José Peña, Inmaculada Tasset, Pedro Montilla

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.

Original language	English (US)
Pages (from-to)	305-310
Number of pages	6
Journal	Letters in Drug Design and Discovery
Volume	4
Issue number	4
DOIs	https://doi.org/10.2174/157018007784620013
State	Published - Jun 1 2007
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Pharmaceutical Science
Drug Discovery

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abstract = "We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.",

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AU - Jimena, Ignacio

AU - Muñoz, María Del C.

AU - Peña, José

AU - Tasset, Inmaculada

AU - Montilla, Pedro

PY - 2007/6/1

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AB - We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.

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Effect of fluoxetine on brain oxidative stress, neuronal damage and behavioural induced in the olfactory bulbectomy model of depression

Abstract

ASJC Scopus subject areas

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