Effect of fluoxetine on brain oxidative stress, neuronal damage and behavioural induced in the olfactory bulbectomy model of depression

Isaac Túnez, Francisco J. Medina, Ignacio Jimena, María Del C. Muñoz, José Peña, Inmaculada Tasset, Pedro Montilla

Research output: Contribution to journalArticle

8 Scopus citations


We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.

Original languageEnglish (US)
Pages (from-to)305-310
Number of pages6
JournalLetters in Drug Design and Discovery
Issue number4
Publication statusPublished - Jun 1 2007
Externally publishedYes


ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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