Effect of elevations of coronary artery partial pressure of carbon dioxide (PCO2) on coronary blood flow

E. R. Powers, K. S. Bannerman, Ingrid A. Fitz-James, P. J. Cannon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This study was designed to examine the effect of increases in the partial pressure of carbon dioxide (PCO2) in coronary artery blood on coronary blood flow, coronary reactive hyperemia and the coronary response to intracoronary adenosine administration. The left anterior descending coronary artery was cannulated and perfused over a wide range of perfusion pressure (P) and flow (F) with blood equilibrated with 0 to 40% carbon dioxide in 16 open chest dogs. Increases in coronary artery PCO2 from 20 ± 2 to 93 ± 8 to 211 ± 22 mm Hg (mean ± SEM) increased the coronary flow from 28 ± 3 to 68 ± 16 to 87 ± 22 ml/min, respectively, at a perfusion pressure of 60 mm Hg and from 49 ± 6 to 139 ± 30 to 206 ± 48 ml/min, respectively, at a perfusion pressure of 100 mm Hg. Coronary reactive hyperemia following a 30 second coronary perfusion line occlusion and the response to an intracoronary bolus of adenosine (60 μg) were prominent at a low PCO2 but absent at a high PCO2. Beta-adrenergic blockage did not abolish the increase in coronary flow that occurred at increased PCO2. Thus, progressive elevations of regional coronary PCO2 produced substantial increases in coronary blood flow and maximal or near maximal coronary vasodilation.

Original languageEnglish (US)
Pages (from-to)1175-1181
Number of pages7
JournalJournal of the American College of Cardiology
Volume8
Issue number5
StatePublished - 1986
Externally publishedYes

Fingerprint

Partial Pressure
Carbon Dioxide
Coronary Vessels
Perfusion
Hyperemia
Pressure
Adenosine
Vasodilation
Adrenergic Agents
Thorax
Dogs

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Effect of elevations of coronary artery partial pressure of carbon dioxide (PCO2) on coronary blood flow. / Powers, E. R.; Bannerman, K. S.; Fitz-James, Ingrid A.; Cannon, P. J.

In: Journal of the American College of Cardiology, Vol. 8, No. 5, 1986, p. 1175-1181.

Research output: Contribution to journalArticle

@article{c723059f7c3d4be791290946e04d5a54,
title = "Effect of elevations of coronary artery partial pressure of carbon dioxide (PCO2) on coronary blood flow",
abstract = "This study was designed to examine the effect of increases in the partial pressure of carbon dioxide (PCO2) in coronary artery blood on coronary blood flow, coronary reactive hyperemia and the coronary response to intracoronary adenosine administration. The left anterior descending coronary artery was cannulated and perfused over a wide range of perfusion pressure (P) and flow (F) with blood equilibrated with 0 to 40{\%} carbon dioxide in 16 open chest dogs. Increases in coronary artery PCO2 from 20 ± 2 to 93 ± 8 to 211 ± 22 mm Hg (mean ± SEM) increased the coronary flow from 28 ± 3 to 68 ± 16 to 87 ± 22 ml/min, respectively, at a perfusion pressure of 60 mm Hg and from 49 ± 6 to 139 ± 30 to 206 ± 48 ml/min, respectively, at a perfusion pressure of 100 mm Hg. Coronary reactive hyperemia following a 30 second coronary perfusion line occlusion and the response to an intracoronary bolus of adenosine (60 μg) were prominent at a low PCO2 but absent at a high PCO2. Beta-adrenergic blockage did not abolish the increase in coronary flow that occurred at increased PCO2. Thus, progressive elevations of regional coronary PCO2 produced substantial increases in coronary blood flow and maximal or near maximal coronary vasodilation.",
author = "Powers, {E. R.} and Bannerman, {K. S.} and Fitz-James, {Ingrid A.} and Cannon, {P. J.}",
year = "1986",
language = "English (US)",
volume = "8",
pages = "1175--1181",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Effect of elevations of coronary artery partial pressure of carbon dioxide (PCO2) on coronary blood flow

AU - Powers, E. R.

AU - Bannerman, K. S.

AU - Fitz-James, Ingrid A.

AU - Cannon, P. J.

PY - 1986

Y1 - 1986

N2 - This study was designed to examine the effect of increases in the partial pressure of carbon dioxide (PCO2) in coronary artery blood on coronary blood flow, coronary reactive hyperemia and the coronary response to intracoronary adenosine administration. The left anterior descending coronary artery was cannulated and perfused over a wide range of perfusion pressure (P) and flow (F) with blood equilibrated with 0 to 40% carbon dioxide in 16 open chest dogs. Increases in coronary artery PCO2 from 20 ± 2 to 93 ± 8 to 211 ± 22 mm Hg (mean ± SEM) increased the coronary flow from 28 ± 3 to 68 ± 16 to 87 ± 22 ml/min, respectively, at a perfusion pressure of 60 mm Hg and from 49 ± 6 to 139 ± 30 to 206 ± 48 ml/min, respectively, at a perfusion pressure of 100 mm Hg. Coronary reactive hyperemia following a 30 second coronary perfusion line occlusion and the response to an intracoronary bolus of adenosine (60 μg) were prominent at a low PCO2 but absent at a high PCO2. Beta-adrenergic blockage did not abolish the increase in coronary flow that occurred at increased PCO2. Thus, progressive elevations of regional coronary PCO2 produced substantial increases in coronary blood flow and maximal or near maximal coronary vasodilation.

AB - This study was designed to examine the effect of increases in the partial pressure of carbon dioxide (PCO2) in coronary artery blood on coronary blood flow, coronary reactive hyperemia and the coronary response to intracoronary adenosine administration. The left anterior descending coronary artery was cannulated and perfused over a wide range of perfusion pressure (P) and flow (F) with blood equilibrated with 0 to 40% carbon dioxide in 16 open chest dogs. Increases in coronary artery PCO2 from 20 ± 2 to 93 ± 8 to 211 ± 22 mm Hg (mean ± SEM) increased the coronary flow from 28 ± 3 to 68 ± 16 to 87 ± 22 ml/min, respectively, at a perfusion pressure of 60 mm Hg and from 49 ± 6 to 139 ± 30 to 206 ± 48 ml/min, respectively, at a perfusion pressure of 100 mm Hg. Coronary reactive hyperemia following a 30 second coronary perfusion line occlusion and the response to an intracoronary bolus of adenosine (60 μg) were prominent at a low PCO2 but absent at a high PCO2. Beta-adrenergic blockage did not abolish the increase in coronary flow that occurred at increased PCO2. Thus, progressive elevations of regional coronary PCO2 produced substantial increases in coronary blood flow and maximal or near maximal coronary vasodilation.

UR - http://www.scopus.com/inward/record.url?scp=0022446344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022446344&partnerID=8YFLogxK

M3 - Article

C2 - 3093553

AN - SCOPUS:0022446344

VL - 8

SP - 1175

EP - 1181

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 5

ER -