Effect of diabetes upon penile sympathetic nerves in impotent patients

Arnold Melman, David P. Henry, David L. Felten, Brian O’Connor

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Samples of erectile tissue taken from the corpora cavernosa of 16 male diabetic patients suffering from impotence were studied. The content of norepinephrine, which reflects sympathetic nerve activity of that tissue, was significantly lower in insulin-dependent patients 104.2 ± 24.8 (SE) pg/mg wet weight (P<.001) and diet-controlled patients 483.7 ± 103.7 (P<.01) than the normal men (881.7 ± 62.0). Myelinated and unmyelinated nerve fibers were observed intact and unaltered in each group of patients. The results indicated that normally a dense adrenergic innervation of human erectile tissue is present, but that a reduction occurs in norepinephrine content in diabetic patients with impotence. It appears, however, that the anatomic integrity of the sympathetic nerves is intact. The presence of intact nerve fibers along with a diminished content of neurotransmitter suggests the possibility of pharmacologic treatment of impotence.

Original languageEnglish (US)
Pages (from-to)307-317
Number of pages11
JournalSouthern Medical Journal
Volume73
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Erectile Dysfunction
Norepinephrine
Myelinated Nerve Fibers
Nerve Tissue
Unmyelinated Nerve Fibers
Nerve Fibers
Adrenergic Agents
Neurotransmitter Agents
Insulin
Diet
Weights and Measures
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Melman, A., Henry, D. P., Felten, D. L., & O’Connor, B. (1980). Effect of diabetes upon penile sympathetic nerves in impotent patients. Southern Medical Journal, 73(3), 307-317.

Effect of diabetes upon penile sympathetic nerves in impotent patients. / Melman, Arnold; Henry, David P.; Felten, David L.; O’Connor, Brian.

In: Southern Medical Journal, Vol. 73, No. 3, 1980, p. 307-317.

Research output: Contribution to journalArticle

Melman, A, Henry, DP, Felten, DL & O’Connor, B 1980, 'Effect of diabetes upon penile sympathetic nerves in impotent patients', Southern Medical Journal, vol. 73, no. 3, pp. 307-317.
Melman A, Henry DP, Felten DL, O’Connor B. Effect of diabetes upon penile sympathetic nerves in impotent patients. Southern Medical Journal. 1980;73(3):307-317.
Melman, Arnold ; Henry, David P. ; Felten, David L. ; O’Connor, Brian. / Effect of diabetes upon penile sympathetic nerves in impotent patients. In: Southern Medical Journal. 1980 ; Vol. 73, No. 3. pp. 307-317.
@article{269871e373334e34ad51347fed9f8b1f,
title = "Effect of diabetes upon penile sympathetic nerves in impotent patients",
abstract = "Samples of erectile tissue taken from the corpora cavernosa of 16 male diabetic patients suffering from impotence were studied. The content of norepinephrine, which reflects sympathetic nerve activity of that tissue, was significantly lower in insulin-dependent patients 104.2 ± 24.8 (SE) pg/mg wet weight (P<.001) and diet-controlled patients 483.7 ± 103.7 (P<.01) than the normal men (881.7 ± 62.0). Myelinated and unmyelinated nerve fibers were observed intact and unaltered in each group of patients. The results indicated that normally a dense adrenergic innervation of human erectile tissue is present, but that a reduction occurs in norepinephrine content in diabetic patients with impotence. It appears, however, that the anatomic integrity of the sympathetic nerves is intact. The presence of intact nerve fibers along with a diminished content of neurotransmitter suggests the possibility of pharmacologic treatment of impotence.",
author = "Arnold Melman and Henry, {David P.} and Felten, {David L.} and Brian O’Connor",
year = "1980",
language = "English (US)",
volume = "73",
pages = "307--317",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effect of diabetes upon penile sympathetic nerves in impotent patients

AU - Melman, Arnold

AU - Henry, David P.

AU - Felten, David L.

AU - O’Connor, Brian

PY - 1980

Y1 - 1980

N2 - Samples of erectile tissue taken from the corpora cavernosa of 16 male diabetic patients suffering from impotence were studied. The content of norepinephrine, which reflects sympathetic nerve activity of that tissue, was significantly lower in insulin-dependent patients 104.2 ± 24.8 (SE) pg/mg wet weight (P<.001) and diet-controlled patients 483.7 ± 103.7 (P<.01) than the normal men (881.7 ± 62.0). Myelinated and unmyelinated nerve fibers were observed intact and unaltered in each group of patients. The results indicated that normally a dense adrenergic innervation of human erectile tissue is present, but that a reduction occurs in norepinephrine content in diabetic patients with impotence. It appears, however, that the anatomic integrity of the sympathetic nerves is intact. The presence of intact nerve fibers along with a diminished content of neurotransmitter suggests the possibility of pharmacologic treatment of impotence.

AB - Samples of erectile tissue taken from the corpora cavernosa of 16 male diabetic patients suffering from impotence were studied. The content of norepinephrine, which reflects sympathetic nerve activity of that tissue, was significantly lower in insulin-dependent patients 104.2 ± 24.8 (SE) pg/mg wet weight (P<.001) and diet-controlled patients 483.7 ± 103.7 (P<.01) than the normal men (881.7 ± 62.0). Myelinated and unmyelinated nerve fibers were observed intact and unaltered in each group of patients. The results indicated that normally a dense adrenergic innervation of human erectile tissue is present, but that a reduction occurs in norepinephrine content in diabetic patients with impotence. It appears, however, that the anatomic integrity of the sympathetic nerves is intact. The presence of intact nerve fibers along with a diminished content of neurotransmitter suggests the possibility of pharmacologic treatment of impotence.

UR - http://www.scopus.com/inward/record.url?scp=0019278819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019278819&partnerID=8YFLogxK

M3 - Article

VL - 73

SP - 307

EP - 317

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 3

ER -