Effect of dextroamphetamine and methylphenidate on calcium and magnesium concentration in hyperactive boys

Mark E. Schmidt; Markus J.P. Kruesi; Josephine Elia; Breck G. Borcherding; Ronald J. Elin; J. M. Hosseini; Kathleen E. McFarlin; Susan Hamburger

doi:10.1016/0165-1781(94)90007-8

Effect of dextroamphetamine and methylphenidate on calcium and magnesium concentration in hyperactive boys

Mark E. Schmidt, Markus J.P. Kruesi, Josephine Elia, Breck G. Borcherding, Ronald J. Elin, J. M. Hosseini, Kathleen E. McFarlin, Susan Hamburger

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Levels of calcium in plasma, red blood cells, and mononuclear blood cells, levels of calcium in plasma, and the plasma calcium-to-magnesium ratio were measured at baseline and after 3 weeks of each drug phase of a double-blind, placebo-controlled study of methylphenidate and dextroamphetamine in hyperactive boys. Levels of magnesium in plasma were significantly higher after 3 weeks of dextroamphetamine treatment, and the calcium-to-magnesium ratio was significantly lower after 3 weeks of either drug compared with the baseline or placebo condition. There was no change in magnesium levels in red blood cells or mononuclear blood cells. These measures were obtained 30 minutes before the morning dose and at 9 a.m., 9:30 a.m., 10:30 a.m., 11:00 a.m., and noon on the last day of each 3-week phase. Analysis of variacne revealed a drug effect on plasma magnesium and on the calcium-to-magnisium ratio but no drug × time interaction. Although these changes were not correlated with the time course of acute symptomatic response to stimulant therapy, the decrease in the ratio may be relevant to side effects and treatment resistance associated with stimulant use.

Original language	English (US)
Pages (from-to)	199-210
Number of pages	12
Journal	Psychiatry Research
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/0165-1781(94)90007-8
State	Published - Nov 1994
Externally published	Yes

Keywords

Attention deficit disorder
amphetamine
erythrocytes
plasma

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(94)90007-8

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title = "Effect of dextroamphetamine and methylphenidate on calcium and magnesium concentration in hyperactive boys",

abstract = "Levels of calcium in plasma, red blood cells, and mononuclear blood cells, levels of calcium in plasma, and the plasma calcium-to-magnesium ratio were measured at baseline and after 3 weeks of each drug phase of a double-blind, placebo-controlled study of methylphenidate and dextroamphetamine in hyperactive boys. Levels of magnesium in plasma were significantly higher after 3 weeks of dextroamphetamine treatment, and the calcium-to-magnesium ratio was significantly lower after 3 weeks of either drug compared with the baseline or placebo condition. There was no change in magnesium levels in red blood cells or mononuclear blood cells. These measures were obtained 30 minutes before the morning dose and at 9 a.m., 9:30 a.m., 10:30 a.m., 11:00 a.m., and noon on the last day of each 3-week phase. Analysis of variacne revealed a drug effect on plasma magnesium and on the calcium-to-magnisium ratio but no drug × time interaction. Although these changes were not correlated with the time course of acute symptomatic response to stimulant therapy, the decrease in the ratio may be relevant to side effects and treatment resistance associated with stimulant use.",

keywords = "Attention deficit disorder, amphetamine, erythrocytes, plasma",

author = "Schmidt, {Mark E.} and Kruesi, {Markus J.P.} and Josephine Elia and Borcherding, {Breck G.} and Elin, {Ronald J.} and Hosseini, {J. M.} and McFarlin, {Kathleen E.} and Susan Hamburger",

year = "1994",

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doi = "10.1016/0165-1781(94)90007-8",

language = "English (US)",

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AU - Schmidt, Mark E.

AU - Kruesi, Markus J.P.

AU - Elia, Josephine

AU - Borcherding, Breck G.

AU - Elin, Ronald J.

AU - Hosseini, J. M.

AU - McFarlin, Kathleen E.

AU - Hamburger, Susan

PY - 1994/11

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N2 - Levels of calcium in plasma, red blood cells, and mononuclear blood cells, levels of calcium in plasma, and the plasma calcium-to-magnesium ratio were measured at baseline and after 3 weeks of each drug phase of a double-blind, placebo-controlled study of methylphenidate and dextroamphetamine in hyperactive boys. Levels of magnesium in plasma were significantly higher after 3 weeks of dextroamphetamine treatment, and the calcium-to-magnesium ratio was significantly lower after 3 weeks of either drug compared with the baseline or placebo condition. There was no change in magnesium levels in red blood cells or mononuclear blood cells. These measures were obtained 30 minutes before the morning dose and at 9 a.m., 9:30 a.m., 10:30 a.m., 11:00 a.m., and noon on the last day of each 3-week phase. Analysis of variacne revealed a drug effect on plasma magnesium and on the calcium-to-magnisium ratio but no drug × time interaction. Although these changes were not correlated with the time course of acute symptomatic response to stimulant therapy, the decrease in the ratio may be relevant to side effects and treatment resistance associated with stimulant use.

AB - Levels of calcium in plasma, red blood cells, and mononuclear blood cells, levels of calcium in plasma, and the plasma calcium-to-magnesium ratio were measured at baseline and after 3 weeks of each drug phase of a double-blind, placebo-controlled study of methylphenidate and dextroamphetamine in hyperactive boys. Levels of magnesium in plasma were significantly higher after 3 weeks of dextroamphetamine treatment, and the calcium-to-magnesium ratio was significantly lower after 3 weeks of either drug compared with the baseline or placebo condition. There was no change in magnesium levels in red blood cells or mononuclear blood cells. These measures were obtained 30 minutes before the morning dose and at 9 a.m., 9:30 a.m., 10:30 a.m., 11:00 a.m., and noon on the last day of each 3-week phase. Analysis of variacne revealed a drug effect on plasma magnesium and on the calcium-to-magnisium ratio but no drug × time interaction. Although these changes were not correlated with the time course of acute symptomatic response to stimulant therapy, the decrease in the ratio may be relevant to side effects and treatment resistance associated with stimulant use.

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KW - amphetamine

KW - erythrocytes

KW - plasma

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Effect of dextroamphetamine and methylphenidate on calcium and magnesium concentration in hyperactive boys

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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