Effect of auditory constraints on motor performance depends on stage of recovery post-stroke

Viswanath Aluru, Ying Lu, Alan Leung, Joe Verghese, Preeti Raghavan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In order to develop evidence-based rehabilitation protocols post-stroke, one must first reconcile the vast heterogeneity in the post-stroke population and develop protocols to facilitate motor learning in the various subgroups. The main purpose of this study is to show that auditory constraints interact with the stage of recovery post-stroke to influence motor learning. We characterized the stages of upper limb recovery using task-based kinematic measures in 20 subjects with chronic hemiparesis. We used a bimanual wrist extension task, performed with a custom-made wrist trainer, to facilitate learning of wrist extension in the paretic hand under four auditory conditions: (1) without auditory cueing; (2) to non-musical happy sounds; (3) to self-selected music; and (4) to a metronome beat set at a comfortable tempo. Two bimanual trials (15 s each) were followed by one unimanual trial with the paretic hand over six cycles under each condition. Clinical metrics, wrist and arm kinematics, and electromyographic activity were recorded. Hierarchical cluster analysis with the Mahalanobis metric based on baseline speed and extent of wrist movement stratified subjects into three distinct groups, which reflected their stage of recovery: spastic paresis, spastic co-contraction, and minimal paresis. In spastic paresis, the metronome beat increased wrist extension, but also increased muscle co-activation across the wrist. In contrast, in spastic co-contraction, no auditory stimulation increased wrist extension and reduced co-activation. In minimal paresis, wrist extension did not improve under any condition. The results suggest that auditory task constraints interact with stage of recovery during motor learning after stroke, perhaps due to recruitment of distinct neural substrates over the course of recovery. The findings advance our understanding of the mechanisms of progression of motor recovery and lay the foundation for personalized treatment algorithms post-stroke.

Original languageEnglish (US)
Article number106
JournalFrontiers in Neurology
Volume5 JUN
DOIs
StatePublished - 2014

Fingerprint

Wrist
Stroke
Paresis
Muscle Spasticity
Learning
Biomechanical Phenomena
Hand
Acoustic Stimulation
Music
Upper Extremity
Cluster Analysis
Arm
Rehabilitation
Muscles
Population

Keywords

  • Bimanual movements
  • Cerebrovascular disorders
  • Electromyography
  • Motor learning/training
  • Rehabilitation
  • Task specificity
  • Upper extremity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Effect of auditory constraints on motor performance depends on stage of recovery post-stroke. / Aluru, Viswanath; Lu, Ying; Leung, Alan; Verghese, Joe; Raghavan, Preeti.

In: Frontiers in Neurology, Vol. 5 JUN, 106, 2014.

Research output: Contribution to journalArticle

Aluru, Viswanath ; Lu, Ying ; Leung, Alan ; Verghese, Joe ; Raghavan, Preeti. / Effect of auditory constraints on motor performance depends on stage of recovery post-stroke. In: Frontiers in Neurology. 2014 ; Vol. 5 JUN.
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