Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection

Oscar Zaragoza, Coralia Mihu, Arturo Casadevall, Joshua D. Nosanchuk

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.

Original languageEnglish (US)
Pages (from-to)4358-4361
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume49
Issue number10
DOIs
StatePublished - Oct 1 2005

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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