Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection

Oscar Zaragoza, Coralia Mihu, Arturo Casadevall, Joshua D. Nosanchuk

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.

Original languageEnglish (US)
Pages (from-to)4358-4361
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number10
DOIs
StatePublished - Oct 2005

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Cryptococcus neoformans
Amphotericin B
Cell Size
Capsules
Cryptococcosis
Phagocytes
Infection
Polysaccharides
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Effect of amphotericin B on capsule and cell size in Cryptococcus neoformans during murine infection. / Zaragoza, Oscar; Mihu, Coralia; Casadevall, Arturo; Nosanchuk, Joshua D.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 10, 10.2005, p. 4358-4361.

Research output: Contribution to journalArticle

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