Effect of a Single Brief Seizure on Subsequent Seizure Susceptibility in the Immature Rat

Gregory L. Holmes, Bruce J. Albala, Solomon L. Moshé

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

To determine whether a single seizure permanently affects the brain's susceptibility to further seizures, 27-day-old rats were subjected to a single seizure induced by either an electroshock or the administration of pentylenetetrazol. Three days following the seizure, the rats, along with age- and weight-matched control rats, underwent kindling. The rate of kindling did not differ between the control rats and those rats that had previously experienced a single electroshock or pentylenetetrazol-induced seizure. At the present time, there is no conclusive evidence that a single brief seizure results in permanently increased susceptibility to future convulsions.

Original languageEnglish (US)
Pages (from-to)853-855
Number of pages3
JournalArchives of Neurology
Volume41
Issue number8
DOIs
StatePublished - Aug 1984

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Effect of a Single Brief Seizure on Subsequent Seizure Susceptibility in the Immature Rat'. Together they form a unique fingerprint.

  • Cite this