Effect of a contralateral lesion on neurological recovery from stroke in rats

Fen Sun; Lin Xie; Xiaoou Mao; Justin Hill; David A. Greenberg; Kunlin Jin

doi:10.3233/RNN-2012-120254

Effect of a contralateral lesion on neurological recovery from stroke in rats

Fen Sun, Lin Xie, Xiaoou Mao, Justin Hill, David A. Greenberg, Kunlin Jin

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.

Original language	English (US)
Pages (from-to)	491-495
Number of pages	5
Journal	Restorative Neurology and Neuroscience
Volume	30
Issue number	6
DOIs	https://doi.org/10.3233/RNN-2012-120254
State	Published - 2012
Externally published	Yes

Keywords

Stroke
ischemia
rat
recovery

ASJC Scopus subject areas

Neurology
Developmental Neuroscience
Clinical Neurology

Access to Document

10.3233/RNN-2012-120254

Cite this

@article{b9f20c2d9d7f4915817a292ab23b818c,

title = "Effect of a contralateral lesion on neurological recovery from stroke in rats",

abstract = "Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.",

keywords = "Stroke, ischemia, rat, recovery",

author = "Fen Sun and Lin Xie and Xiaoou Mao and Justin Hill and Greenberg, {David A.} and Kunlin Jin",

year = "2012",

doi = "10.3233/RNN-2012-120254",

language = "English (US)",

volume = "30",

pages = "491--495",

journal = "Restorative Neurology and Neuroscience",

issn = "0922-6028",

publisher = "IOS Press",

number = "6",

}

TY - JOUR

T1 - Effect of a contralateral lesion on neurological recovery from stroke in rats

AU - Sun, Fen

AU - Xie, Lin

AU - Mao, Xiaoou

AU - Hill, Justin

AU - Greenberg, David A.

AU - Jin, Kunlin

PY - 2012

Y1 - 2012

N2 - Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.

AB - Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.

KW - Stroke

KW - ischemia

KW - rat

KW - recovery

UR - http://www.scopus.com/inward/record.url?scp=84872226262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872226262&partnerID=8YFLogxK

U2 - 10.3233/RNN-2012-120254

DO - 10.3233/RNN-2012-120254

M3 - Article

C2 - 22868223

AN - SCOPUS:84872226262

SN - 0922-6028

VL - 30

SP - 491

EP - 495

JO - Restorative Neurology and Neuroscience

JF - Restorative Neurology and Neuroscience

IS - 6

ER -

Effect of a contralateral lesion on neurological recovery from stroke in rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this