Effect of a contralateral lesion on neurological recovery from stroke in rats

Fen Sun, Lin Xie, Xiaoou Mao, Justin Hill, David A. Greenberg, Kunlin Jin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery after experimental stroke.

Original languageEnglish (US)
Pages (from-to)491-495
Number of pages5
JournalRestorative Neurology and Neuroscience
Volume30
Issue number6
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

Fingerprint

Middle Cerebral Artery Infarction
Stroke
Cerebral Cortex
Walking
Sprague Dawley Rats
Young Adult
Extremities
Staining and Labeling

Keywords

  • ischemia
  • rat
  • recovery
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Effect of a contralateral lesion on neurological recovery from stroke in rats. / Sun, Fen; Xie, Lin; Mao, Xiaoou; Hill, Justin; Greenberg, David A.; Jin, Kunlin.

In: Restorative Neurology and Neuroscience, Vol. 30, No. 6, 01.12.2012, p. 491-495.

Research output: Contribution to journalArticle

Sun, Fen ; Xie, Lin ; Mao, Xiaoou ; Hill, Justin ; Greenberg, David A. ; Jin, Kunlin. / Effect of a contralateral lesion on neurological recovery from stroke in rats. In: Restorative Neurology and Neuroscience. 2012 ; Vol. 30, No. 6. pp. 491-495.
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