Effect of 17 β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats

Inmaculada Tasset; José Peña; Ignacio Jimena; Montserrat Feijóo; María del Carmern Muñoz; Pedro Montilla; Isaac Túnez

Effect of 17 β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats

Inmaculada Tasset, José Peña, Ignacio Jimena, Montserrat Feijóo, María del Carmern Muñoz, Pedro Montilla, Isaac Túnez

Research output: Contribution to journal › Article › peer-review

Abstract

The present study evaluated 17β-estradiol (17βE₂) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE₂ (14 days). Our results reveled that 17βE₂ has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.

Original language	English (US)
Pages (from-to)	441-449
Number of pages	9
Journal	Neuropsychiatric Disease and Treatment
Volume	4
Issue number	2
State	Published - 2008
Externally published	Yes

Keywords

17 β-estradiol
Behavioral
Depression
Oxidative stress

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The present study evaluated 17β-estradiol (17βE2) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE2 (14 days). Our results reveled that 17βE2 has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.",

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T1 - Effect of 17 β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats

AU - Tasset, Inmaculada

AU - Peña, José

AU - Jimena, Ignacio

AU - Feijóo, Montserrat

AU - del Carmern Muñoz, María

AU - Montilla, Pedro

AU - Túnez, Isaac

PY - 2008

Y1 - 2008

N2 - The present study evaluated 17β-estradiol (17βE2) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE2 (14 days). Our results reveled that 17βE2 has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.

AB - The present study evaluated 17β-estradiol (17βE2) (2.5 mg/kg sc) effects on bilateral OBX-induced behavioral changes and oxidative stress. OBX in male Wistar rats produced an increase in lipid peroxidation products and a decline in reduced glutathione (GSH) content and glutathione peroxidase (GSH-Px) activity, together with an increase in caspase-3 activity. Additionally, OBX triggered changes of behavior such as an enhancement of immobility time in the forced swim test and hyperactivity in the open field test. These changes were reversed by treatment with 17βE2 (14 days). Our results reveled that 17βE2 has a protective effect against oxidative stress, cell damage and behavioral changes induced by OBX, and present antidepressant and antianxiety properties.

KW - 17 β-estradiol

KW - Behavioral

KW - Depression

KW - Oxidative stress

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Effect of 17 β-estradiol on olfactory bulbectomy-induced oxidative stress and behavioral changes in rats

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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