Efecto de la terapia temprana con L-arginina en el crecimiento intrauterino restringido en la preclampsia. Estudio aleatorizado en mujeres latinoamericanas

Translated title of the contribution: Effect of early L-arginine therapy on intrauterine growth restriction in preeclampsia. A randomized controlled trial in Latin-American women

Julio E. Valdivia-Silva, Keisy López-Molina, Rodney Macedo

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objective: To assess the benefit of early L-arginine administration in preeclampsia on the relative risk to fetal growth. Patients and methods: One-hundred women with preeclampsia were randomized to receive either L-arginine or placebo until the day of delivery. To evaluate the relative risk of intrauterine growth restriction (IUGR) and the effect of L-arginine on this process, 96 live singleton infants of women with preeclampsia (50 with treatment and 46 without treatment) were compared; these infants were also compared with a further 50 control infants of healthy women. Gestational age-related birth weight was compared using standard growth curves. Infants smaller than the 10th percentile were classified as IUGR. The Mann-Witney U-test, ANOVA, and chi-square test were used to evaluate statistically significant differences (P<.05) between the groups. Results: No significant differences were found between the groups with preeclampsia before randomization. Preeclampsia was associated with a 21% reduction in birth weight. The risk of IUGR was five times higher in infants born after preeclampsia without L-arginine therapy than in control pregnancies (RR = 5.0; 95%IC: 1.5-16.2) and was two times higher in infants born after preeclampsia with L-arginine therapy (RR = 2.0; 95% CI: 1.9-7.6). The fetal biophysical profile and Apgar score were significantly more favorable in the L-arginine group (P<.05). Conclusion: Fetal growth markedly improves with early L-arginine therapy in women with preeclampsia.

Translated title of the contributionEffect of early L-arginine therapy on intrauterine growth restriction in preeclampsia. A randomized controlled trial in Latin-American women
Original languageSpanish
Pages (from-to)89-98
Number of pages10
JournalProgresos en Obstetricia y Ginecologia
Volume52
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

Keywords

  • Fetal growth
  • Intrauterine growth restriction
  • L-arginine
  • Preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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