@article{129a3b9c50ea4908a77d8b3f79be432c,
title = "Educational Case: Ischemic Disorders of the Gut in Adult Patients",
abstract = "The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.1.",
keywords = "blood supply of gut, gastrointestinal tract, ischemic disorders of the gut, organ system pathology, pathology competencies, vasculitis",
author = "Priyanka Patil and Panarelli, {Nicole C.}",
note = "Funding Information: Intestinal ischemia can result from localized or systemic vascular compromise and preferentially effects intestinal segments with less collateral circulation. The colon is most commonly affected due to the presence of watershed areas like splenic flexure and rectosigmoid area. Intestinal ischemia is a potential complication of commonly used over-the-counter and prescription medications including NSAIDs and oral contraceptive pills. Systemic vasculitides (granulomatosis with polyangiitis, EGPA, PAN, microscopic polyangiitis, leukocytoclastic vasculitis) and autoimmune diseases (SLE, RA) can present with intestinal ischemia. Infections that can cause ischemia (CMV, angioinvasive fungi) are important to consider, particularly in immunocompromised patients. Integration of subtle histologic clues and clinical data may elucidate the cause of intestinal ischemia and guide clinical management in a substantial proportion of cases. Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The article processing fee for this article was supported by an Open Access Award given by the Society of {\textquoteleft}67, which supports the mission of the Association of Pathology Chairs to produce the next generation of outstanding investigators and educational scholars in the field of pathology. This award helps to promote the publication of high-quality original scholarship in Academic Pathology by authors at an early stage of academic development. ORCID iD Priyanka Patil https://orcid.org/0000-0001-6213-044X Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The article processing fee for this article was supported by an Open Access Award given by the Society of ?67, which supports the mission of the Association of Pathology Chairs to produce the next generation of outstanding investigators and educational scholars in the field of pathology. This award helps to promote the publication of high-quality original scholarship in Academic Pathology by authors at an early stage of academic development. Publisher Copyright: {\textcopyright} The Author(s) 2019.",
year = "2019",
doi = "10.1177/2374289519888709",
language = "English (US)",
volume = "6",
journal = "Academic Pathology",
issn = "2374-2895",
publisher = "SAGE Publications Ltd",
}