Edoxaban: A Novel Factor Xa Inhibitor for the Management of Non-valvular Atrial Fibrillation and Venous Thromboembolism

Kara A. Kubli, Jessica A. Snead, Angela Cheng-Lai

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Warfarin has been a highly prevalent agent for over 70 years; however, its use has been limited by drug-drug interactions, adverse events, and the need for frequent monitoring. To minimize these complications, several non-vitamin K oral anticoagulants have been approved, including the latest agent, edoxaban. Edoxaban is a factor Xa inhibitor approved for the prevention of stroke/systemic embolism in patients with non-valvular atrial fibrillation and for the treatment of venous thromboembolism. Edoxaban was largely studied in the Edoxaban versus Warfarin in Patients with Atrial Fibrillation (ENGAGE AF-TIMI 48) and Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism (Hokusai-VTE) trials, both showing noninferiority when compared with warfarin. Similar to other oral anticoagulants, the most serious adverse effects of edoxaban are related to bleeding. However, there are currently no approved reversal agents. Andexanet alfa and ciraparantag are the latest agents being studied for reversal. This article provides an overview of the safety and efficacy along with the advantages and disadvantages of edoxaban.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalCardiology in review
Volume24
Issue number4
DOIs
StatePublished - 2016

Keywords

  • atrial fibrillation
  • deep vein thrombosis
  • edoxaban
  • factor Xa inhibitor
  • oral anticoagulant
  • pulmonary embolism
  • venous thromboembolism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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