Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis

Steven U. Walkley, D. A. Siegel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced α-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalDevelopmental Brain Research
Volume20
Issue number1
DOIs
StatePublished - 1985

Fingerprint

Mannosidase Deficiency Diseases
Gangliosidoses
Swainsonine
Pyramidal Cells
Felidae
Neurites
Staining and Labeling
Growth
Axon Initial Segment

Keywords

  • animal model
  • cortical neuron
  • lysosomes
  • mannosidosis
  • neurite growth
  • storage disease

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis. / Walkley, Steven U.; Siegel, D. A.

In: Developmental Brain Research, Vol. 20, No. 1, 1985, p. 143-148.

Research output: Contribution to journalArticle

@article{fd9fcc12a52c42e3b356219aa577455f,
title = "Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis",
abstract = "Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced α-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.",
keywords = "animal model, cortical neuron, lysosomes, mannosidosis, neurite growth, storage disease",
author = "Walkley, {Steven U.} and Siegel, {D. A.}",
year = "1985",
doi = "10.1016/0165-3806(85)90098-7",
language = "English (US)",
volume = "20",
pages = "143--148",
journal = "Developmental Brain Research",
issn = "0165-3806",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis

AU - Walkley, Steven U.

AU - Siegel, D. A.

PY - 1985

Y1 - 1985

N2 - Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced α-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.

AB - Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced α-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.

KW - animal model

KW - cortical neuron

KW - lysosomes

KW - mannosidosis

KW - neurite growth

KW - storage disease

UR - http://www.scopus.com/inward/record.url?scp=0022263529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022263529&partnerID=8YFLogxK

U2 - 10.1016/0165-3806(85)90098-7

DO - 10.1016/0165-3806(85)90098-7

M3 - Article

C2 - 3924348

AN - SCOPUS:0022069272

VL - 20

SP - 143

EP - 148

JO - Developmental Brain Research

JF - Developmental Brain Research

SN - 0165-3806

IS - 1

ER -