Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis

S. U. Walkley; D. A. Siegel

doi:10.1016/0165-3806(85)90098-7

Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis

S. U. Walkley, D. A. Siegel

Neuroscience

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced α-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.

Original language	English (US)
Pages (from-to)	143-148
Number of pages	6
Journal	Developmental Brain Research
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(85)90098-7
State	Published - May 1985

Keywords

animal model
cortical neuron
lysosomes
mannosidosis
neurite growth
storage disease

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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10.1016/0165-3806(85)90098-7

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title = "Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis",

abstract = "Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced α-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.",

keywords = "animal model, cortical neuron, lysosomes, mannosidosis, neurite growth, storage disease",

author = "Walkley, {S. U.} and Siegel, {D. A.}",

note = "Funding Information: This work was supported by grants from the NIH (NS-18804, NS-03356W). e thank Drs. Kunihiko Suzuki, Henry Baker and Dominick Purpura for helpful discussions, Mrs. M. Buschke and S. Wurzelmann for excellent technicaasl sistancea nd Ms. V. Ahrens for manuscriptp reparation.",

year = "1985",

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doi = "10.1016/0165-3806(85)90098-7",

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journal = "Developmental Brain Research",

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T1 - Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis

AU - Walkley, S. U.

AU - Siegel, D. A.

N1 - Funding Information: This work was supported by grants from the NIH (NS-18804, NS-03356W). e thank Drs. Kunihiko Suzuki, Henry Baker and Dominick Purpura for helpful discussions, Mrs. M. Buschke and S. Wurzelmann for excellent technicaasl sistancea nd Ms. V. Ahrens for manuscriptp reparation.

PY - 1985/5

Y1 - 1985/5

N2 - Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced α-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.

AB - Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced α-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.

KW - animal model

KW - cortical neuron

KW - lysosomes

KW - mannosidosis

KW - neurite growth

KW - storage disease

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Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis

Abstract

Keywords

ASJC Scopus subject areas

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