Ectopic dendritogenesis occurs on cortical pyramidal neurons in swainsonine-induced feline α-mannosidosis

S. U. Walkley, D. A. Siegel

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Golgi staining has revealed that ectopic neurites sprout from the axon-hillock region of cortical pyramidal neurons in kittens with swainsonine-induced α-mannosidosis. These new growth processes appeared qualitatively identical to those reported in a variety of inherited neuronal storage diseases including the gangliosidoses. In the latter, such processes have been shown to be dendritic-like and postsynaptic to afferents of unknown origin. We believe this to be the first demonstration of induced dendritogenesis in the mammalian CNS and a model system which should prove useful in exploring this remarkable phenomenon occurring in neuronal storage disorders.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalDevelopmental Brain Research
Volume20
Issue number1
DOIs
StatePublished - May 1985

Keywords

  • animal model
  • cortical neuron
  • lysosomes
  • mannosidosis
  • neurite growth
  • storage disease

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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