Echolucency of the carotid artery intima-media complex and intima-media thickness have different cardiovascular risk factor relationships

the Women's Interagency HIV Study

Molly Jung, Christina M. Parrinello, Xiaonan (Nan) Xue, Wendy J. Mack, Kathryn Anastos, Jason M. Lazar, Robert H. Selzer, Anne M. Shircore, Michael Plankey, Phyllis Tien, Mardge Cohen, Stephen J. Gange, Howard N. Hodis, Robert C. Kaplan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

BACKGROUND: Adults infected with HIV have increased atherosclerosis potentially associated with both HIV and non-HIV associated factors. We characterized risk factors for atherosclerosis as measured by noninvasive vascular imaging.

METHODS AND RESULTS: We used B-mode ultrasound to examine levels and correlates of echogenicity and vessel wall thickness of the carotid artery intima-media complex in 1282 HIV-infected and 510 HIV-uninfected women of the Women's Interagency HIV Study. Levels of gray scale median (GSM, a measure of echogenicity) did not vary between HIV infection groups. In both groups, smokers had increased GSM, whereas age, diabetes, elevated blood pressure, and high BMI were associated with lower (rather than higher) GSM. Each of these non-lipid CVD risk factors, especially age and blood pressure, was also associated with higher levels of carotid artery intima-media thickness (cIMT). Higher serum triglyceride levels were associated with lower GSM in both HIV-infected and HIV-uninfected groups. Additional lipid risk factors for low GSM including high LDL cholesterol and low HDL cholesterol levels were identified in HIV uninfected but not in HIV infected women. In contrast to findings for GSM, among the lipid parameters only LDL cholesterol level had an association with cIMT, which was observed only in the HIV uninfected group.

CONCLUSIONS: Lipid and non-lipid risk factor associations with echolucency of the carotid artery and the thickness of the common carotid artery intima-media layer suggest that these measures capture different aspects of atherosclerosis.

Original languageEnglish (US)
JournalJournal of the American Heart Association
Volume4
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Carotid Arteries
HIV
Carotid Intima-Media Thickness
Atherosclerosis
Lipids
LDL Cholesterol
Common Carotid Artery
HDL Cholesterol
HIV Infections
Blood Vessels
Triglycerides
Blood Pressure
Hypertension
Serum

Keywords

  • carotid arteries
  • epidemiology
  • immune system
  • risk factors
  • ultrasonics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Echolucency of the carotid artery intima-media complex and intima-media thickness have different cardiovascular risk factor relationships : the Women's Interagency HIV Study. / Jung, Molly; Parrinello, Christina M.; Xue, Xiaonan (Nan); Mack, Wendy J.; Anastos, Kathryn; Lazar, Jason M.; Selzer, Robert H.; Shircore, Anne M.; Plankey, Michael; Tien, Phyllis; Cohen, Mardge; Gange, Stephen J.; Hodis, Howard N.; Kaplan, Robert C.

In: Journal of the American Heart Association, Vol. 4, No. 2, 01.02.2015.

Research output: Contribution to journalArticle

Jung, Molly ; Parrinello, Christina M. ; Xue, Xiaonan (Nan) ; Mack, Wendy J. ; Anastos, Kathryn ; Lazar, Jason M. ; Selzer, Robert H. ; Shircore, Anne M. ; Plankey, Michael ; Tien, Phyllis ; Cohen, Mardge ; Gange, Stephen J. ; Hodis, Howard N. ; Kaplan, Robert C. / Echolucency of the carotid artery intima-media complex and intima-media thickness have different cardiovascular risk factor relationships : the Women's Interagency HIV Study. In: Journal of the American Heart Association. 2015 ; Vol. 4, No. 2.
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abstract = "BACKGROUND: Adults infected with HIV have increased atherosclerosis potentially associated with both HIV and non-HIV associated factors. We characterized risk factors for atherosclerosis as measured by noninvasive vascular imaging.METHODS AND RESULTS: We used B-mode ultrasound to examine levels and correlates of echogenicity and vessel wall thickness of the carotid artery intima-media complex in 1282 HIV-infected and 510 HIV-uninfected women of the Women's Interagency HIV Study. Levels of gray scale median (GSM, a measure of echogenicity) did not vary between HIV infection groups. In both groups, smokers had increased GSM, whereas age, diabetes, elevated blood pressure, and high BMI were associated with lower (rather than higher) GSM. Each of these non-lipid CVD risk factors, especially age and blood pressure, was also associated with higher levels of carotid artery intima-media thickness (cIMT). Higher serum triglyceride levels were associated with lower GSM in both HIV-infected and HIV-uninfected groups. Additional lipid risk factors for low GSM including high LDL cholesterol and low HDL cholesterol levels were identified in HIV uninfected but not in HIV infected women. In contrast to findings for GSM, among the lipid parameters only LDL cholesterol level had an association with cIMT, which was observed only in the HIV uninfected group.CONCLUSIONS: Lipid and non-lipid risk factor associations with echolucency of the carotid artery and the thickness of the common carotid artery intima-media layer suggest that these measures capture different aspects of atherosclerosis.",
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T1 - Echolucency of the carotid artery intima-media complex and intima-media thickness have different cardiovascular risk factor relationships

T2 - the Women's Interagency HIV Study

AU - Jung, Molly

AU - Parrinello, Christina M.

AU - Xue, Xiaonan (Nan)

AU - Mack, Wendy J.

AU - Anastos, Kathryn

AU - Lazar, Jason M.

AU - Selzer, Robert H.

AU - Shircore, Anne M.

AU - Plankey, Michael

AU - Tien, Phyllis

AU - Cohen, Mardge

AU - Gange, Stephen J.

AU - Hodis, Howard N.

AU - Kaplan, Robert C.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - BACKGROUND: Adults infected with HIV have increased atherosclerosis potentially associated with both HIV and non-HIV associated factors. We characterized risk factors for atherosclerosis as measured by noninvasive vascular imaging.METHODS AND RESULTS: We used B-mode ultrasound to examine levels and correlates of echogenicity and vessel wall thickness of the carotid artery intima-media complex in 1282 HIV-infected and 510 HIV-uninfected women of the Women's Interagency HIV Study. Levels of gray scale median (GSM, a measure of echogenicity) did not vary between HIV infection groups. In both groups, smokers had increased GSM, whereas age, diabetes, elevated blood pressure, and high BMI were associated with lower (rather than higher) GSM. Each of these non-lipid CVD risk factors, especially age and blood pressure, was also associated with higher levels of carotid artery intima-media thickness (cIMT). Higher serum triglyceride levels were associated with lower GSM in both HIV-infected and HIV-uninfected groups. Additional lipid risk factors for low GSM including high LDL cholesterol and low HDL cholesterol levels were identified in HIV uninfected but not in HIV infected women. In contrast to findings for GSM, among the lipid parameters only LDL cholesterol level had an association with cIMT, which was observed only in the HIV uninfected group.CONCLUSIONS: Lipid and non-lipid risk factor associations with echolucency of the carotid artery and the thickness of the common carotid artery intima-media layer suggest that these measures capture different aspects of atherosclerosis.

AB - BACKGROUND: Adults infected with HIV have increased atherosclerosis potentially associated with both HIV and non-HIV associated factors. We characterized risk factors for atherosclerosis as measured by noninvasive vascular imaging.METHODS AND RESULTS: We used B-mode ultrasound to examine levels and correlates of echogenicity and vessel wall thickness of the carotid artery intima-media complex in 1282 HIV-infected and 510 HIV-uninfected women of the Women's Interagency HIV Study. Levels of gray scale median (GSM, a measure of echogenicity) did not vary between HIV infection groups. In both groups, smokers had increased GSM, whereas age, diabetes, elevated blood pressure, and high BMI were associated with lower (rather than higher) GSM. Each of these non-lipid CVD risk factors, especially age and blood pressure, was also associated with higher levels of carotid artery intima-media thickness (cIMT). Higher serum triglyceride levels were associated with lower GSM in both HIV-infected and HIV-uninfected groups. Additional lipid risk factors for low GSM including high LDL cholesterol and low HDL cholesterol levels were identified in HIV uninfected but not in HIV infected women. In contrast to findings for GSM, among the lipid parameters only LDL cholesterol level had an association with cIMT, which was observed only in the HIV uninfected group.CONCLUSIONS: Lipid and non-lipid risk factor associations with echolucency of the carotid artery and the thickness of the common carotid artery intima-media layer suggest that these measures capture different aspects of atherosclerosis.

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KW - epidemiology

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