Eccrine gland infiltration by mycosis fungoides

Michael G. Hitchcock, James L. Burchette, Elise A. Olsen, Howard Ratech, Hideko Kamino

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

After identifying prominent eccrine infiltration by atypical lymphocytes in a biopsy of tumor stage mycosis fungoides (MF), we sought to determine the pattern of eccrine epithelial infiltration in MF. The frequency, intensity, and distribution of infiltration of eccrine gland structures, including acrosyringium, duct and coil epithelium, was studied by examining 71 biopsy specimens from 42 patients with MF in which eccrine structures were present. These were obtained from a retrospective review of pathologic specimens from Duke University Medical Center from 1992 and 1993. At least focal eccrine infiltration was noted in 23 of the 71 biopsy specimens (32%). Immunohistochemical confirmation of T-lymphocyte phenotype was performed in the 23 cases with positive reaction to antibodies CD3 and CD45RO and negative reaction with CD20. Folliculosebaceous units were present in 22 of the 71 biopsy specimens and were at least focally involved by MF in 11 (50%) in this series. A control group of biopsy specimens of reactive dermatoses were characterized by more superficial location of lymphocytes, with more spongiosis and epithelial degenerative changes. These findings further illustrate the epitheliotropic behavior of MF.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalAmerican Journal of Dermatopathology
Volume18
Issue number5
DOIs
StatePublished - 1996

Fingerprint

Eccrine Glands
Mycosis Fungoides
Biopsy
Lymphocytes
Skin Diseases
Epithelium
T-Lymphocytes
Phenotype
Control Groups
Antibodies
Neoplasms

Keywords

  • Cutaneous T-cell lymphoma
  • Mycosis fungoides, eccrine
  • Sweat gland
  • Syringolymphoid hyperplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

Cite this

Hitchcock, M. G., Burchette, J. L., Olsen, E. A., Ratech, H., & Kamino, H. (1996). Eccrine gland infiltration by mycosis fungoides. American Journal of Dermatopathology, 18(5), 447-453. https://doi.org/10.1097/00000372-199610000-00001

Eccrine gland infiltration by mycosis fungoides. / Hitchcock, Michael G.; Burchette, James L.; Olsen, Elise A.; Ratech, Howard; Kamino, Hideko.

In: American Journal of Dermatopathology, Vol. 18, No. 5, 1996, p. 447-453.

Research output: Contribution to journalArticle

Hitchcock, MG, Burchette, JL, Olsen, EA, Ratech, H & Kamino, H 1996, 'Eccrine gland infiltration by mycosis fungoides', American Journal of Dermatopathology, vol. 18, no. 5, pp. 447-453. https://doi.org/10.1097/00000372-199610000-00001
Hitchcock, Michael G. ; Burchette, James L. ; Olsen, Elise A. ; Ratech, Howard ; Kamino, Hideko. / Eccrine gland infiltration by mycosis fungoides. In: American Journal of Dermatopathology. 1996 ; Vol. 18, No. 5. pp. 447-453.
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