Early visual processing deficits in schizophrenia: Impaired PI generation revealed by high-density electrical mapping

John J. Foxe, Glen M. Doniger, Daniel C. Javitt

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

Integrity of early visual sensory processing in schizophrenia was assessed using the well characterized PI and NI components of the visual evoked potential (VEP) as our dependent measures. VEPs were recorded in response to successively less fragmented line drawings of common objects. PI amplitudes were significantly reduced across all stimulus conditions for patients versus controls. Further, this decrement was relatively greater at parieto-occipital than occipito-temporal electrode sites. No differences in NI amplitude were found. The finding of PI deficits in patients, particularly over dorsal scalp, supports the view that schizophrenia is associated with impairment of early dorsal visual stream processing. On the other hand, the finding of normal NI amplitudes in patients suggests that early stages of ventral stream processing may be relatively more intact. These results imply that the cognitive impairment seen in schizophrenia is not just due to deficits in higher order aspects of cognition but also encompasses significant deficits in early sensory processing.

Original languageEnglish (US)
Pages (from-to)3815-3820
Number of pages6
JournalNeuroReport
Volume12
Issue number17
DOIs
StatePublished - Dec 4 2001

Keywords

  • Dorsal stream
  • ERP
  • Event-related potentials
  • High-density mapping
  • PI component
  • Schizophrenia
  • VEP
  • Visual cortex
  • Visual evoked potential

ASJC Scopus subject areas

  • Neuroscience(all)

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