Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia

Gary Donohoe, Derek W. Morris, Pierfilippo De Sanctis, Elena Magno, Jennifer L. Montesi, Hugh P. Garavan, Ian H. Robertson, Daniel C. Javitt, Michael Gill, Aiden P. Corvin, John J. Foxe

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. The relationship between dysbindin risk variants and sensory-level deficits in schizophrenia remains to be explored. We investigated P1 performance, a component of early visual processing on which both patients and their relatives show deficits, in carriers and noncarriers of a known dysbindin risk haplotype. Methods: Event-related potential responses to simple visual isolated-check stimuli were measured using high-density electrical scalp recordings in 26 individuals meeting DSM-IV criteria for schizophrenia, comprising 14 patients who were carriers of the dysbindin risk haplotype and 12 patients who were nonrisk haplotype carriers. Results: Carriers of the dysbindin risk haplotype demonstrated significantly reduced P1 amplitudes compared with noncarriers. A large effect size of d = .89 was calculated for the difference in P1 amplitude over scalp sites where the deficit was maximal. Conclusions: The P1 deficits associated with a dysbindin risk haplotype previously identified in our sample presents functional confirmation of its deleterious effect on brain activity. Building on evidence of dysbindin's role in higher cognitive function, these early visual processing deficits suggest a generalized role for dysbindin in brain function and is likely to be part of the mechanism by which illness susceptibility is mediated.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalBiological Psychiatry
Volume63
Issue number5
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

Fingerprint

Schizophrenia
Haplotypes
Scalp
Brain
Evoked Potentials
Diagnostic and Statistical Manual of Mental Disorders
Cognition
Genes

Keywords

  • Dysbindin
  • EEG
  • ERP
  • P1
  • schizophrenia
  • sensory processing

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Donohoe, G., Morris, D. W., De Sanctis, P., Magno, E., Montesi, J. L., Garavan, H. P., ... Foxe, J. J. (2008). Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia. Biological Psychiatry, 63(5), 484-489. https://doi.org/10.1016/j.biopsych.2007.07.022

Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia. / Donohoe, Gary; Morris, Derek W.; De Sanctis, Pierfilippo; Magno, Elena; Montesi, Jennifer L.; Garavan, Hugh P.; Robertson, Ian H.; Javitt, Daniel C.; Gill, Michael; Corvin, Aiden P.; Foxe, John J.

In: Biological Psychiatry, Vol. 63, No. 5, 01.03.2008, p. 484-489.

Research output: Contribution to journalArticle

Donohoe, G, Morris, DW, De Sanctis, P, Magno, E, Montesi, JL, Garavan, HP, Robertson, IH, Javitt, DC, Gill, M, Corvin, AP & Foxe, JJ 2008, 'Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia', Biological Psychiatry, vol. 63, no. 5, pp. 484-489. https://doi.org/10.1016/j.biopsych.2007.07.022
Donohoe G, Morris DW, De Sanctis P, Magno E, Montesi JL, Garavan HP et al. Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia. Biological Psychiatry. 2008 Mar 1;63(5):484-489. https://doi.org/10.1016/j.biopsych.2007.07.022
Donohoe, Gary ; Morris, Derek W. ; De Sanctis, Pierfilippo ; Magno, Elena ; Montesi, Jennifer L. ; Garavan, Hugh P. ; Robertson, Ian H. ; Javitt, Daniel C. ; Gill, Michael ; Corvin, Aiden P. ; Foxe, John J. / Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia. In: Biological Psychiatry. 2008 ; Vol. 63, No. 5. pp. 484-489.
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