Naloxone hydrochloride (N) 0.4-1.2 mg i.v. was administered during 10 episodes of shock (8 septic and 2 cardiogenic) in 9 adult patients. Shock was defined as systolic blood pressure (SBP) ≤90 mmHg and urine output <0.5 ml/h and signs and symptoms of hypoperfusion lasting for >-30 min, despite fluid loading to a CVP 5 cmH2O above baseline. N was given as early as 30 min after onset of shock and resulted in an increase of SBP from a mean of 75 ± 10 to a mean of 130 ± 25 mmHg maximum (P < 0.01). Within 10-60 min urine output increased from 16 ± 12 to 122 ± 56 ml/h, heart rate, CVP and arterial blood gas tensions remained unchanged. No side effects were observed. Naloxone, even in small doses, may improve hemodynamic parameters in human shock, provided it is administered very early.
ASJC Scopus subject areas
- Emergency Medicine
- Cardiology and Cardiovascular Medicine