TY - JOUR
T1 - Early-stage HIV infection and hepatitis C virus infection are associated with elevated serum porphyrin levels
AU - Lim, H. W.
AU - Pereira, A.
AU - Sassa, S.
AU - Kim, M.
AU - Zolla-Pazner, S.
N1 - Funding Information:
Supported in part by National Institutes of Health grants AI 32424 and AI 27742, and by a Department of Veterans Affairs Merit Review Grant and the Research Center for AIDS and HIV Infection.
PY - 1998
Y1 - 1998
N2 - Background: Porphyria cutanea tarda is known to be associated with HIV infection and hepatitis C virus (HCV). Objective: Our purpose was to evaluate whether early infection with HIV, with or without HCV infection, is associated with elevated serum porphyrin levels. Methods: Serum porphyrin levels were measured in samples obtained from 103 patients with early HIV infection. The results were compared with those of 89 late-stage HIV-positive patients and 78 HIV-negative patients. Results: The highest median porphyrin level was in early-stage HIV-positive/HCV-positive samples, followed in decreasing order by those in early-stage HIV-positive/HCV-negative, late- stage HIV-positive/HCV-positive, late-stage HIV-positive/HCV-negative, HIV- negative/HCV-positive, and HIV-negative/HCV-negative groups. Elevated porphyrin levels were independently associated with early-stage HIV infection (P < .0001) and HCV infection (P = .03). Conclusion: This finding suggests abnormal porphyrin metabolism is most noticeable in early-stage HIV infection; it becomes less severe with the progression of HIV disease.
AB - Background: Porphyria cutanea tarda is known to be associated with HIV infection and hepatitis C virus (HCV). Objective: Our purpose was to evaluate whether early infection with HIV, with or without HCV infection, is associated with elevated serum porphyrin levels. Methods: Serum porphyrin levels were measured in samples obtained from 103 patients with early HIV infection. The results were compared with those of 89 late-stage HIV-positive patients and 78 HIV-negative patients. Results: The highest median porphyrin level was in early-stage HIV-positive/HCV-positive samples, followed in decreasing order by those in early-stage HIV-positive/HCV-negative, late- stage HIV-positive/HCV-positive, late-stage HIV-positive/HCV-negative, HIV- negative/HCV-positive, and HIV-negative/HCV-negative groups. Elevated porphyrin levels were independently associated with early-stage HIV infection (P < .0001) and HCV infection (P = .03). Conclusion: This finding suggests abnormal porphyrin metabolism is most noticeable in early-stage HIV infection; it becomes less severe with the progression of HIV disease.
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U2 - 10.1016/S0190-9622(98)70269-5
DO - 10.1016/S0190-9622(98)70269-5
M3 - Article
C2 - 9843008
AN - SCOPUS:0031733635
SN - 0190-9622
VL - 39
SP - 956
EP - 959
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6
ER -
