Early intervention for obsessive compulsive disorder

An expert consensus statement

Naomi A. Fineberg, Bernardo Dell'Osso, Umberto Albert, Giuseppe Maina, Daniel Geller, Lior Carmi, Nick Sireau, Susanne Walitza, Giacomo Grassi, Stefano Pallanti, Eric Hollander, Vlasios Brakoulias, Jose M. Menchon, Donatella Marazziti, Konstantinos Ioannidis, Annemieke Apergis-Schoute, Dan J. Stein, Danielle C. Cath, Dick J. Veltman, Michael Van Ameringen & 5 others Leonardo F. Fontenelle, Roseli G. Shavitt, Daniel Costa, Juliana B. Diniz, Joseph Zohar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Obsessive-compulsive disorder (OCD) is common, emerges early in life and tends to run a chronic, impairing course. Despite the availability of effective treatments, the duration of untreated illness (DUI) is high (up to around 10 years in adults) and is associated with considerable suffering for the individual and their families. This consensus statement represents the views of an international group of expert clinicians, including child and adult psychiatrists, psychologists and neuroscientists, working both in high and low and middle income countries, as well as those with the experience of living with OCD. The statement draws together evidence from epidemiological, clinical, health economic and brain imaging studies documenting the negative impact associated with treatment delay on clinical outcomes, and supporting the importance of early clinical intervention. It draws parallels between OCD and other disorders for which early intervention is recognized as beneficial, such as psychotic disorders and impulsive-compulsive disorders associated with problematic usage of the Internet, for which early intervention may prevent the development of later addictive disorders. It also generates new heuristics for exploring the brain-based mechanisms moderating the ‘toxic’ effect of an extended DUI in OCD. The statement concludes that there is a global unmet need for early intervention services for OC related disorders to reduce the unnecessary suffering and costly disability associated with under-treatment. New clinical staging models for OCD that may be used to facilitate primary, secondary and tertiary prevention within this context are proposed.

Original languageEnglish (US)
JournalEuropean Neuropsychopharmacology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Obsessive-Compulsive Disorder
Consensus
Psychological Stress
Tertiary Prevention
Poisons
Primary Prevention
Secondary Prevention
Neuroimaging
Internet
Psychotic Disorders
Psychiatry
Therapeutics
Economics
Psychology
Health
Brain

Keywords

  • Compulsive
  • Duration of untreated illness
  • Early intervention
  • Obsessive
  • OCD
  • Staging

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

Cite this

Early intervention for obsessive compulsive disorder : An expert consensus statement. / Fineberg, Naomi A.; Dell'Osso, Bernardo; Albert, Umberto; Maina, Giuseppe; Geller, Daniel; Carmi, Lior; Sireau, Nick; Walitza, Susanne; Grassi, Giacomo; Pallanti, Stefano; Hollander, Eric; Brakoulias, Vlasios; Menchon, Jose M.; Marazziti, Donatella; Ioannidis, Konstantinos; Apergis-Schoute, Annemieke; Stein, Dan J.; Cath, Danielle C.; Veltman, Dick J.; Van Ameringen, Michael; Fontenelle, Leonardo F.; Shavitt, Roseli G.; Costa, Daniel; Diniz, Juliana B.; Zohar, Joseph.

In: European Neuropsychopharmacology, 01.01.2019.

Research output: Contribution to journalArticle

Fineberg, NA, Dell'Osso, B, Albert, U, Maina, G, Geller, D, Carmi, L, Sireau, N, Walitza, S, Grassi, G, Pallanti, S, Hollander, E, Brakoulias, V, Menchon, JM, Marazziti, D, Ioannidis, K, Apergis-Schoute, A, Stein, DJ, Cath, DC, Veltman, DJ, Van Ameringen, M, Fontenelle, LF, Shavitt, RG, Costa, D, Diniz, JB & Zohar, J 2019, 'Early intervention for obsessive compulsive disorder: An expert consensus statement', European Neuropsychopharmacology. https://doi.org/10.1016/j.euroneuro.2019.02.002
Fineberg, Naomi A. ; Dell'Osso, Bernardo ; Albert, Umberto ; Maina, Giuseppe ; Geller, Daniel ; Carmi, Lior ; Sireau, Nick ; Walitza, Susanne ; Grassi, Giacomo ; Pallanti, Stefano ; Hollander, Eric ; Brakoulias, Vlasios ; Menchon, Jose M. ; Marazziti, Donatella ; Ioannidis, Konstantinos ; Apergis-Schoute, Annemieke ; Stein, Dan J. ; Cath, Danielle C. ; Veltman, Dick J. ; Van Ameringen, Michael ; Fontenelle, Leonardo F. ; Shavitt, Roseli G. ; Costa, Daniel ; Diniz, Juliana B. ; Zohar, Joseph. / Early intervention for obsessive compulsive disorder : An expert consensus statement. In: European Neuropsychopharmacology. 2019.
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AU - Brakoulias, Vlasios

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AU - Veltman, Dick J.

AU - Van Ameringen, Michael

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