Abstract
Antiretroviral therapy (ART) is associated with dyslipidemia and cardiovascular disease in adults infected with HIV. For children perinatally infected with HIV, ART exposure is lifelong and early-onset dyslipidemia could have significant long-term effects. We examined cholesterol levels in children during the first year after exposure to a new ART regimen (initiation or switch). In 52 children, total cholesterol increased by 30.5 and 43 mg/dL at 6 and 12 months, respectively (P < 0.001). Low-density lipoprotein cholesterol made the largest contribution, but high-density lipoprotein cholesterol also increased within months of therapy alteration. Early identification of these children and intervention could mediate potential increased risk for future cardiovascular disease.
Original language | English (US) |
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Pages (from-to) | 495-498 |
Number of pages | 4 |
Journal | Journal of pediatric gastroenterology and nutrition |
Volume | 52 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2011 |
Externally published | Yes |
Keywords
- HDL
- HIV
- LDL
- antiretroviral therapy
- dyslipidemia
- hypercholesterolemia
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Gastroenterology