Early experience with a polymethyl pentene oxygenator for adult extracorporeal life support

Giles J. Peek, Hilliary M. Killer, Richard Reeves, Andrezj W. Sosnowski, Richard K. Firmin

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Silicone oxygenators are the standard devices used for Extra-corporeal Life Support (ECLS), but they have some limitations. Microporous polypropylene hollow fiber oxygenators overcome many of these problems but, unfortunately, develop plasma leak. Polymethyl-pentene (PMP) is a novel oxygenator material. We report our initial experience with the Medos Hilite 7000LT, a PMP hollow fiber oxygenator, in six adult respiratory ECLS patients with these characteristics: age, mean 32.2 (±13) years; weight, mean 81.2 (±17) kg; PaO2/FIO2, mean 62.8 [±33] mm Hg; Murray Score, mean 3.4 [±0.3]; and sepsis related organ failure assessment score, mean 9.6 [±2.3]. One patient was cannulated within 10 hours of multiple trauma and 1 hour after thoracolaparotomy; another patient was cannulated 12 hours after a thoracotomy. All six patients survived. Heparin was infused (7.8-32.5 u/kg/hr) to maintain activated clotting time at 162 to 238 seconds; international normalized ratio was 0.9 to 3.4. Two of the six patients required transfusions of fresh frozen plasma, receiving one and five units, respectively. Fibrinogen was 1.4 to 6 g/dl; no cryoprecipitate was needed. Platelet counts were between 65 and 306, and very little platelet transfusion (mean 2.33; ± 3.03 units per patient) was required to maintain these levels. Two patients did not require any platelet transfusion. Maximum blood flow was 5.3 L/min, sweep was 3 to 10 L/min, and resistance was 11 to 43 Paul Wood Units. There were no oxygenator failures. Mean duration of ECLS was 151.7 hours (±75.6). Our initial experience with PMP oxygenators in adults was satisfactory, and platelet consumption and resistance to blood flow seem to be greatly reduced with PMP.

Original languageEnglish (US)
Pages (from-to)480-482
Number of pages3
JournalASAIO Journal
Volume48
Issue number5
StatePublished - Sep 2002
Externally publishedYes

Fingerprint

Oxygenators
Extracorporeal Membrane Oxygenation
Alkenes
Platelets
Platelet Transfusion
Blood
Plasmas
Organ Dysfunction Scores
Fibers
Polypropylenes
Silicones
International Normalized Ratio
Multiple Trauma
Fibrinogen
Thoracotomy
Heparin
Platelet Count
Wood
Sepsis
Blood Platelets

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Peek, G. J., Killer, H. M., Reeves, R., Sosnowski, A. W., & Firmin, R. K. (2002). Early experience with a polymethyl pentene oxygenator for adult extracorporeal life support. ASAIO Journal, 48(5), 480-482.

Early experience with a polymethyl pentene oxygenator for adult extracorporeal life support. / Peek, Giles J.; Killer, Hilliary M.; Reeves, Richard; Sosnowski, Andrezj W.; Firmin, Richard K.

In: ASAIO Journal, Vol. 48, No. 5, 09.2002, p. 480-482.

Research output: Contribution to journalArticle

Peek, GJ, Killer, HM, Reeves, R, Sosnowski, AW & Firmin, RK 2002, 'Early experience with a polymethyl pentene oxygenator for adult extracorporeal life support', ASAIO Journal, vol. 48, no. 5, pp. 480-482.
Peek GJ, Killer HM, Reeves R, Sosnowski AW, Firmin RK. Early experience with a polymethyl pentene oxygenator for adult extracorporeal life support. ASAIO Journal. 2002 Sep;48(5):480-482.
Peek, Giles J. ; Killer, Hilliary M. ; Reeves, Richard ; Sosnowski, Andrezj W. ; Firmin, Richard K. / Early experience with a polymethyl pentene oxygenator for adult extracorporeal life support. In: ASAIO Journal. 2002 ; Vol. 48, No. 5. pp. 480-482.
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