Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease

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Abstract

Mouse models of lysosomal storage diseases, including Sandhoff disease, are frequently employed to test therapies directed at the central nervous system. We backbred such mice and conducted a behavioral test battery which included sensorimotor and cognitive assessments. This is the first report of short-term memory deficits in a murine model of Sandhoff disease. We also document early onset of motor deficits using the balance beam test.

Original languageEnglish (US)
Pages (from-to)315-319
Number of pages5
JournalBehavioural Brain Research
Volume193
Issue number2
DOIs
StatePublished - Nov 21 2008

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Keywords

  • Balance beam
  • Memory
  • Motor coordination
  • Mouse model
  • Novel object recognition test
  • Open field
  • Rotarod
  • Sandhoff disease

ASJC Scopus subject areas

  • Behavioral Neuroscience

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