Abstract
Mouse models of lysosomal storage diseases, including Sandhoff disease, are frequently employed to test therapies directed at the central nervous system. We backbred such mice and conducted a behavioral test battery which included sensorimotor and cognitive assessments. This is the first report of short-term memory deficits in a murine model of Sandhoff disease. We also document early onset of motor deficits using the balance beam test.
Original language | English (US) |
---|---|
Pages (from-to) | 315-319 |
Number of pages | 5 |
Journal | Behavioural Brain Research |
Volume | 193 |
Issue number | 2 |
DOIs | |
State | Published - Nov 21 2008 |
Keywords
- Balance beam
- Memory
- Motor coordination
- Mouse model
- Novel object recognition test
- Open field
- Rotarod
- Sandhoff disease
ASJC Scopus subject areas
- Behavioral Neuroscience