Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mouse models of lysosomal storage diseases, including Sandhoff disease, are frequently employed to test therapies directed at the central nervous system. We backbred such mice and conducted a behavioral test battery which included sensorimotor and cognitive assessments. This is the first report of short-term memory deficits in a murine model of Sandhoff disease. We also document early onset of motor deficits using the balance beam test.

Original languageEnglish (US)
Pages (from-to)315-319
Number of pages5
JournalBehavioural Brain Research
Volume193
Issue number2
DOIs
StatePublished - Nov 21 2008

Fingerprint

Sandhoff Disease
Lysosomal Storage Diseases
Memory Disorders
Short-Term Memory
Central Nervous System
Cognitive Dysfunction
Therapeutics

Keywords

  • Balance beam
  • Memory
  • Motor coordination
  • Mouse model
  • Novel object recognition test
  • Open field
  • Rotarod
  • Sandhoff disease

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

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