Early Aggressive Intraocular Pressure Lowering, Target Intraocular Pressure, and a Novel Concept for Glaucoma Care

Kuldev Singh, Anurag Shrivastava

Research output: Contribution to journalArticle

7 Scopus citations


Early diagnosis of glaucomatous optic nerve damage offers the potential for early treatment which may prevent vision loss from this neurodegenerative disease. Even in patients who do not begin early treatment, early diagnosis allows for better monitoring of disease at a stage where the stakes are lower relative to later stages of the disease. For these reasons, early diagnosis of glaucomatous optic nerve disease is desirable and opens the door for appropriately aggressive therapy. The target intraocular pressure (IOP) concept is widely employed by glaucoma practitioners. Although there have been no randomized clinical trials or other high-quality studies showing the benefits of setting a target IOP versus not using this approach, there is ample evidence that lowering IOP slows glaucoma progression and, in general, lower is better, regardless of disease stage and baseline IOP level. We propose an alternative approach to managing glaucoma without the use of the target IOP concept and suggest that this market IOP concept should be compared with the target IOP approach in an appropriately powered comparative clinical trial.

Original languageEnglish (US)
Pages (from-to)S33-S38
JournalSurvey of Ophthalmology
Issue number6 SUPPL.
StatePublished - Nov 1 2008
Externally publishedYes



  • early diagnosis
  • early treatment
  • glaucoma
  • intraocular pressure (IOP)
  • market IOP
  • target IOP

ASJC Scopus subject areas

  • Ophthalmology

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