E and P selectins are not required for resistance to severe murine lyme arthritis

K. P. Seiler, Y. Ma, J. H. Weis, P. S. Frenette, R. O. Hynes, D. D. Wagner, J. J. Weis

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Abstract

Borrelia burgdorferi-induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of nentrophils to sites of inflammation, mice with this deficiency were tested for their response to infection with B. burgdorferi. E and P selectins were not required for the control of B. burgdorferi numbers, nor did deficiency in E and P selectins result in alteration of arthritis severity.

Original languageEnglish (US)
Pages (from-to)4557-4559
Number of pages3
JournalInfection and Immunity
Volume66
Issue number9
StatePublished - Sep 9 1998

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ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Seiler, K. P., Ma, Y., Weis, J. H., Frenette, P. S., Hynes, R. O., Wagner, D. D., & Weis, J. J. (1998). E and P selectins are not required for resistance to severe murine lyme arthritis. Infection and Immunity, 66(9), 4557-4559.