Borrelia burgdorferi-induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of nentrophils to sites of inflammation, mice with this deficiency were tested for their response to infection with B. burgdorferi. E and P selectins were not required for the control of B. burgdorferi numbers, nor did deficiency in E and P selectins result in alteration of arthritis severity.
|Original language||English (US)|
|Number of pages||3|
|Journal||Infection and Immunity|
|State||Published - Sep 9 1998|
ASJC Scopus subject areas
- Infectious Diseases